[gavinray]

I've used Retatrutide and wasn't that impressed

I used 5mg/wk

(Have used Semaglutide, Tirzepatide, and Retatrutide. For Sema/Tirz, I've had both RX and grey market.)

[glp1guide]

Interesting -- would love to hear anything more you have to share! The research numbers would suggest that Reta was top, results wise.

Any other significant differences you felt/noticed? Also, do you find Tirz to be an imiprovement over Sema?

[gavinray]

Yes, so far my preference has been Tirz. Though cost for Sema is significantly less.

It could also be the case that the dose on the Reta I used was too low. I've had a few people mention that they also felt it was fairly weak mg-for-mg, maybe 10mg would have been better.

There is a newer formulation, combining Sema with Cagrilintide that is probably the most effective option atm:

https://www.nejm.org/doi/full/10.1056/NEJMoa2502081

Price wise, this should give a general idea what Chinese sources sell at:

  Semaglutide 10mg/vial x 10vials $80
  Tirzepatide 10mg/vial x 10vials $72
  Retatrutide 10mg/vial x 10vials $130
  Cagrilintide 5mg + Semaglutide 5mg 10mg/vial x 10vials $170

(Note that even though Tirz is a few dollars cheaper, 2.5mg Sema = 15mg Tirz or thereabouts)

[glp1guide]

Sorry a bit late here, but the numbers for CagriSema are actually not as good as Retatrutide's were. Unless I'm missing something:

Reta 8mg -22% body weight at 48 weeks

CagriSema -20.4% body weight at 68 weeks

CagriSema has been on my radar for a while, and it's certainly going to be exciting.

Here's a slightly better link for the curious:

https://pubmed.ncbi.nlm.nih.gov/40544433/

https://clinicaltrials.gov/study/NCT05567796

[b112]

The problem with online is, were all those Reddit posts you saw just astroturfers? And the whole point, to drum up funding for Reta? Or buzz?

One person can easily turf as 1000 too, posting from a few accounts every day over the course of a year.

[cthalupa]

The studies for Reta are showing gangbusters results. And it's being developed by Eli Lilly, so they hardly need funding.

I swapped to Reta from Tirz and have found it to be a significantly better option myself.

[glp1guide]

This is a valid concern but the subreddits I'm thinking about are not quite that -- no one is selling or trying to push you to some distributor, it's a lot of the bodybuilding/peptide crowd. More like walking into a classic forum thread than modern reddit. You can tell by the comments.