Reta 8mg -22% body weight at 48 weeks
CagriSema -20.4% body weight at 68 weeks
CagriSema has been on my radar for a while, and it's certainly going to be exciting.
Here's a slightly better link for the curious:
https://pubmed.ncbi.nlm.nih.gov/40544433/
https://clinicaltrials.gov/study/NCT05567796