[gavinray]

Yes, so far my preference has been Tirz. Though cost for Sema is significantly less.

It could also be the case that the dose on the Reta I used was too low. I've had a few people mention that they also felt it was fairly weak mg-for-mg, maybe 10mg would have been better.

There is a newer formulation, combining Sema with Cagrilintide that is probably the most effective option atm:

https://www.nejm.org/doi/full/10.1056/NEJMoa2502081

Price wise, this should give a general idea what Chinese sources sell at:

  Semaglutide 10mg/vial x 10vials $80
  Tirzepatide 10mg/vial x 10vials $72
  Retatrutide 10mg/vial x 10vials $130
  Cagrilintide 5mg + Semaglutide 5mg 10mg/vial x 10vials $170

(Note that even though Tirz is a few dollars cheaper, 2.5mg Sema = 15mg Tirz or thereabouts)

[glp1guide]

Sorry a bit late here, but the numbers for CagriSema are actually not as good as Retatrutide's were. Unless I'm missing something:

Reta 8mg -22% body weight at 48 weeks

CagriSema -20.4% body weight at 68 weeks

CagriSema has been on my radar for a while, and it's certainly going to be exciting.

Here's a slightly better link for the curious:

https://pubmed.ncbi.nlm.nih.gov/40544433/

https://clinicaltrials.gov/study/NCT05567796