He's a poor debater in that video, and he's begging the question in many cases.
He actually agrees with Lustig that highly processed food is addictive (he gives different reasons), but he pretends to disagree (go virality!). He's inventing strawmen in order to have something to argue with. They are actually making the same prescription but for different reasons: eat less processed food and reduce caloric intake if you want to lose weight.
He agrees that fruit is harder to consume, and is therefore a better vehicle to consume fructose if one is trying to limit caloric intake.
The intestine is made of intestinal epithelial cells, bound together by proteins to form a barrier. That class of proteins is called tight-junction proteins (eg zonulin). Fructose nitrates those proteins, causing them to be transiently permeable, allowing some of the sewage in your intestine to enter your bloodstream, leading to leaky gut. Leaky gut leads to inflammation of the liver, which leads to systemic inflammation. A biomarker of that inflammatory immune response is creactive protein (CRP). Lustic says 93% of Americans have leaky gut.
It'll answer your question.