[lustig_reader]

Here's Lustig's argument, lightly paraphrased:

The intestine is made of intestinal epithelial cells, bound together by proteins to form a barrier. That class of proteins is called tight-junction proteins (eg zonulin). Fructose nitrates those proteins, causing them to be transiently permeable, allowing some of the sewage in your intestine to enter your bloodstream, leading to leaky gut. Leaky gut leads to inflammation of the liver, which leads to systemic inflammation. A biomarker of that inflammatory immune response is creactive protein (CRP). Lustic says 93% of Americans have leaky gut.

Transcript for reference: https://www.happyscribe.com/public/huberman-lab/dr-82a32683-...