He's a poor debater in that video, and he's begging the question in many cases.
He actually agrees with Lustig that highly processed food is addictive (he gives different reasons), but he pretends to disagree (go virality!). He's inventing strawmen in order to have something to argue with. They are actually making the same prescription but for different reasons: eat less processed food and reduce caloric intake if you want to lose weight.
He agrees that fruit is harder to consume, and is therefore a better vehicle to consume fructose if one is trying to limit caloric intake.