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by maybeOneDay 1593 days ago
Tangential: Is there any evidence that pro biotic foods or supplements can increase gut health? Given the evident importance of gut health, I wonder whether it's worth using something like this, to grab a random example: https://www.amazon.co.uk/Restored-Bio-Cultures/dp/B082SZXBF2...
10 comments

Another anecdata point:

I used be lethargic, couldn't get myself to do anything but be on the sofa. I would get horrible migraine headaches if drinking alcohol or even alcohol free beer or eat certain foods. I self-diagnosed histamine intolerance through trial and error.

I tried multiple pro-biotic combinations. An easy one I tried in the beginning was simply some Danone Actimel the family had in the fridge anyway. I can attest to the fact that it contains live bacteria (a strain that makes lots of histamines) that do make it to the gut because it gave me the horrible migraine headache as would Sauerkraut actually. Researched what strains don't create lots of histamine. I landed on Garden of Life - Primal Defense Ultra. What I think made the difference is that it contains Bacillus subtilis. I say that because I tried two or three others that had largely the same makeup of strains but none had that particular bacterium. It's a soil based bacterium which you might get from eating your own cabbage you grew in the garden as well. Almost everything else just has various different strains of lactobacilli.

Taking 3 capsules a day I felt like crap for 2 weeks (no headaches, just feeling sick, like a bad cold) and then things got better. I am able to drink alcohol again (I'll get a hangover headache like anyone would if I drink too much but it's not longer a day long migraine from just sipping 10ml) and eat anything I want to in any quantity. I still take one in the morning and one in the evening and I put one into the Sauerkraut I make.

YMMV as always, not a doctor, try at your own risk, not affiliated etc :)

Really interesting indeed! I just found this paper on B. subtilis from November: https://pubmed.ncbi.nlm.nih.gov/34630666/

Reducing intestinal permeability is a highly desirable effect.

It's the same bacteria found in Natto
Thanks for sharing this, most of your experience sounds similar to those of a friend of mine (Yokult gives them migraines) although they haven't yet tried Bacillus subtillis.
Probiotic and gut biome research is all over the place.

It’s possible to find some studies showing correlations, but it’s harder to find successful replications of those studies.

Some probiotics have been shown to temporarily alter gut flora, but it usually reverts after the probiotic is stopped. Dietary and activity changes are generally good at improving the biome.

It doesn’t help that one of the commercial guy biome measuring companies basically turned out to be fraudulent a few years ago. Even some of the public efforts to measure correlations are suspect or bunk because they relied on these services.

As a fellow comment says - its all over the place and kind of hard to say, see [1] saying they are useless but lots of studies saying they are useful .

Personally as someone with IBS, I have tried many probiotics over the years and have mixed results - most of them were useless but for some time I found one or 2 that worked but I couldnt say for sure if they worked due to other factors (for e.g generally healthier food, lifestyle, mindset etc). You would have to try it out for weeks to see their effect (according to studies that say it work).

The doctors I spoke to though gave me strong probiotics (>100 billion CFU, for e.g something like [2]). I found anything that had 1 or 10 billion CFU to be pretty much useless.

I think you should work on your diet before taking probiotics. I dont think I am lactose intolerant, milk gives me bad bloating but yogurt doesnt. Yogurt worked for me over the course of weeks, kefir and sauerkrat gave me mega-bloating.

[1] https://www.bbc.com/news/health-45434753 [2] https://www.amazon.com/Visbiome-Potency-Probiotic-Shipped-Sh...

Not sure if you have heard of the low FODMAP diet? Its now the standard treatment for IBS. The theory is certain bacteria ferment FODMAPS into gas and water which leads to the symptoms. They don't know which bacteria yet but going low fodmap is now a well researched and accepted treatment.

Everyone is different but personally, I'm able to tolerate everything except Fructans (one of several types of FODMAPS). So no garlic, onion or wheat for me.

https://www.monashfodmap.com/ibs-central/i-have-ibs/starting...

Yes of course. I did low-fodmap for many months few years ago and continue to do it (when I go to an unknown place for example or travel).

In studies Low-fodmap is typically only recommended for ~6 weeks. I now try to eat any kind food though, I eat everything in smaller quantities and this also helps.

I personally found that a combination of diet, stress, sleep control are the most effective for managing IBS symptoms. Any one of those can flare up the symptoms at any time and managing all of them is key

I was skeptical of this when I first heard of it several years ago. It sounded just like every other popular diet does: “Just (don’t) eat this certain food, and you will feel amazing!”

But I have several family members on it right now, and they all report feeling WAY better. And this is after years of dealing with IBS type problems too.

Another successful patient of the low FODMAP diet here. As soon as I stray from the restrictions I will suffer the next day. IBS can be crippling.

Honestly the scientist(s) who developed the low FODMAP diet needs to be awarded a Nobel prize.

It's the same for me. If I eat the wrong food, I'll feel fine for the rest of that day.

Then the next day, almost always in the morning is when the problems will start. Perhaps the bacteria had time to ferment the food overnight.

So when I have symptoms, I always look at what I ate the previous day.

Low FODMAP works, but it’s precisely because it’s unlike all other “diets”. It’s a systematic removal of basically all short-chain sugars. The problem with it, as someone who was instructed to follow it, is that it’s extremely unintuitive to know what foods are low or high FODMAP without the list. Because of this, it’s really easy to make mistakes unless you consult the list prior to eating.

So it definitely gives positive results, but it’s also very difficult to follow.

As someone on FODMAP, what works for me is to do breakfast/lunch meal replacement with low FODMAP shakes (like Huel), then get a few FODMAP cookbooks and make dinners out of that. Works great and is fairly painless - lots of delicious meals can be made that are low fodmap, fortunately. It's really difficult to avoid FODMAPs when eating out, western food loves onions and garlic for instance - for these cases, I use alpha-glucosidase enzyme tablets (I take 2x 350mg tablets with a meal).
Yep, there are hundreds of foods out there that have them.

Personally I use this app when eating anything I'm not sure about, it has a database of foods and their fodmap content: https://www.monashfodmap.com/ibs-central/i-have-ibs/get-the-...

Eat fiber. Meet the recommended amount and eat a diverse set of fiber which will feed different microbes in the gut. It will take some time for the gut to adjust to the new levels though. Expect gas, cramping, etc for a few days.
Do you advise just fiber from natural foods, or do you take a fiber supplement (like those that come in powder form)? I guess the supplement route won't give me the diverse fiber types you mention, am I right?
Grandparent said eat, not supplement. Eating nutritionless food and then trying to backfill with supplementation is counter-productive.
Anecdata: Tried various probiotics, no help. Pre-biotics however, have been huge. Search for "resistant starch".
The best treatment for my own ADHD, depression and anxiety is living a healthy lifestyle, across the board, full stop.

It means regular exercise, 6 hours of cardio a week, eating healthy, meditating, spending time in the sun, etc. etc. (And anti-depressants/therapy, which play an important role too.)

Of course, it's too much to tell someone struggling to do all those things, but if you can work towards that, I strongly recommend it. I've had to declare war on my depression and ADHD because I can't afford to have it in my life anymore.

At some point perhaps the science will catch up and explain precisely how these things help, but until then, I feel like you have to take the ancient approach of observing people who have things figured out and emulating them. (And I say this as someone who is very much pro-science.)

What was your diet like when you were taking them? It's been observed in some studies that delivered mixed results that responders had better diets (i.e. more bacteria friendly components in the diet such as indigestible carbs from vegetables/legumes/fruit etc) whereas non-responders had weaker diets in terms of providing the gut microbes nutrients.
Diet is now generally low-FODMAP, emphasis on reducing fructose, glucose, and sugar alcohols e.g. sorbitol, erythritol, to which I seem especially sensitive -- this may be atypical among IBS patients.
I've come across plenty of evidence in the literature but there are lot of variables that can prevent any positive effects from taking place. If you're taking probiotic supplements in isolation and the rest of your diet is suboptimal in terms of bacteria-friendly nutrients, it's unlikely that you'll get results. It could be the case that many people are throwing money away if they're taking probiotic supplements without addressing their diet and lifestyle.

There's so much variety between people, one formulation for one person might work well for one person but have negative effects on another even if they have a supportive diet and lifestyle. People might simply have to trial multiple formulas that have the right mix of strains before they find one that works for them.

Prebiotic foods seem to have more consistent results on gut health, according to some studies.

(not medical/health advice disclaimer)

Sauerkraut is simple to make and cabbage is cheap.

https://www.livestrong.com/article/413921-does-sauerkraut-ha...

Personally kefir, sauerkraut, kimchi, kombucha - all give me lots of bloating even after trying out for weeks. Maybe thats just how its supposed to be? Not sure but I stopped after a while after it affected my daily life
I brew my own kefir, sauerkraut, kimchi, and occasionally kombucha. Of those kefir is the most demonstrably effective, all of them are cheap.

The only effective probiotics I've found are very expensive, costing around $120/mo.

> The only effective probiotics I've found are very expensive,

But how do you know if they're effective?

That's always been my question.

What is the effect one should notice?

I have some odd GI issues so there's a clear impact there. The alternative treatment is some very nasty medication. Effective probiotics restore normality without the side effects the medications have. I'll spare you the details ;)

More anecdotally I do feel generally better even when my GI symptoms aren't present: more energy, better mood, more restful sleep.

Or Kimchi if you're into Korean food.
Do you have an easy to make recipe?
I use a variant of Emmymade's variant of Maangchi's recipe. It works really well.

Rinsed pickle jars work great, a head of Napa cabbage usually fills about 2+1/2 ~ 3 jars. If you're not into high spicy, dial back the red pepper by about half, for your first try. If you don't like funky, skip the fish sauce or any seafood component, I always do this so that the flavor won't clash with some dishes, you can always add fish sauce to a dish but you can't remove it.

I ferment it for about 3 days at about 65 ~ 68 degrees(f), then into the fridge. It keeps indefinitely but is best within a few months.

Do not bring it into work, just as you would not microwave fish at work. The aroma is very much not to everyone's preference, even when made without seafood.

https://www.youtube.com/watch?v=vaoA7SKN0g0 https://www.maangchi.com/recipe/easy-kimchi

it would never have occured to me not to bring kimchi to work. Durian? Stinky Tofu? ok but Kimchee? I'll bet most company cafeterias have blue cheese around
Not GP and don't have one to suggest, but as you're asking for 'easy' (and at risk of stating the obvious, but only once you know I suppose) - ignore anything that says something like 'refigerate for 30mins and enjoy'.

Or don't, I'm not denying quick such er salads can taste great, just that if what you want is a fermented or pickled product, that takes time. (And much longer if at all in the fridge - that's their purpose!)

A 'proper' recipe for sauerkraut for example will tell you something on the order of weeks at minimum, and it's done when you like the taste. Kimchi I think is typically fermented for longer, more like months or over a year (not including any transferred to the next batch).

Most lactofermented foods are: Main ingredient, spices, a few tbsp of salt. Add to sterile jar, fill with water (add a glass weight to the top if needed to keep everything submerged) and leave in a dark cabinet for a few weeks. Trial and error to get the flavor the way you want it, but that's basically it. If you see little air bubbles forming near the bottom after 2-4 days, you have a live culture.
https://www.thekitchn.com/how-to-make-easy-kimchi-at-home-18...

good base to build from, it didn't use to be so spammy tho

Rather than using these processed foods, one should provide the gut microbiome with “food” in the form of fiber from whole plant foods, i.e. not ‘fiber’ supplements like Metamucil.

Lots of accessible information can be found at https://nutritionfacts.org.

https://pendulumlife.com/pages/science

From the maker but I heard about it on a podcast and was convinced.

I've always been prescribed them by doctors after taking antibiotics... As you guessed it the guy microbes are killed off by the medication.

Well that's the theory anyway...