Hacker News new | ask | show | jobs
by Gauge_Irrahphe 1789 days ago
It's from the lack of heavy metals - lead is necessary for transporting glucose to the axon, and its deficiency leads to massive synapse loss and resulting mental illness.

The data that supposedly prove heavy metal toxicity are extremely suspect, sometimes outright bizarre. 1. They are elements, so no major changes could possibly occur. Thry appear in all recent geological history. 2. Their toxicity somehow went unnoticed until recently. There are no records of cadmium being considered toxic before 1970. Somehow nobody noticed the toxicity of the most toxic known metal. Thallium was noticed to be toxic soon after its discovery. Lead was only known to cause poisonings in very large amounts and mostly limited to breathing exposure, and was used in things like make up and even sweeteners. Presumably any noticeable toxicity would prevent it from being used in such cases. 3. The purpoted mechanism is absurd. The body picks the metals to be incorporated proteins with great accuracy, and pick the heavy metal, which poisons the protein and activates it when it should be inactive. It just sounds completely absurd to me. 4. Heavy metals only accumulate until certain concentrations are reached, then they start getting excreted. This effect is widely noted.

2 comments

> It's from the lack of heavy metals - lead is necessary for transporting glucose to the axon, and its deficiency leads to massive synapse loss and resulting mental illness.

I'm going to need a reference for this because I was under the impression that there is no safe level for lead in the body, and it serves no biological purpose.

I can't download the paper. I'm sorry, but reading the abstract, I don't see how that paper supports your argument.

"Highlights

• Chronic Pb exposure could result in a lower weight gain in rats and a higher Pb content in the brain of model rats.

• Pb exposure reduced activities of key enzymes of glucose metabolism in the brain.

• Pb exposure could disrupt the insulin signaling pathway in the hippocampus of rats."

Lower insulin is good. Some of these proteins are targeted by Rapamycin.

The glucose transports are increased, (GLUT3 is the one that supplies axons) and the rats weighed less.

Interesting. Any references, further reading?
See the link above. Also notice the supression of mTOR.