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by ashleyn 1792 days ago
> It's from the lack of heavy metals - lead is necessary for transporting glucose to the axon, and its deficiency leads to massive synapse loss and resulting mental illness.

I'm going to need a reference for this because I was under the impression that there is no safe level for lead in the body, and it serves no biological purpose.

1 comments

I can't download the paper. I'm sorry, but reading the abstract, I don't see how that paper supports your argument.

"Highlights

• Chronic Pb exposure could result in a lower weight gain in rats and a higher Pb content in the brain of model rats.

• Pb exposure reduced activities of key enzymes of glucose metabolism in the brain.

• Pb exposure could disrupt the insulin signaling pathway in the hippocampus of rats."

Lower insulin is good. Some of these proteins are targeted by Rapamycin.

The glucose transports are increased, (GLUT3 is the one that supplies axons) and the rats weighed less.