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by bad_user 2104 days ago
And yet, most of what you said is bullshit that's not evidence based.

"Autophagy", that famous process which supposedly happens during fasting, that miraculously regenerates us, actually happens during caloric restriction, and it's actually a daily process that happens during the night, in everyone, while glycogen stores get naturally depleted.

And we have no evidence that increased autophagy levels are beneficial, quite the contrary, we have some evidence that, right after fasting, the immune system is suppressed. The bigger the caloric restriction, the larger effect on refeeding. An effect very relevant for malnourished populations that suddenly get access to food.

This is basically modern quackery, medical technobabble lacking any evidence other than obscure studies done on mice.

What "healers" and witches used to do, but taken to the next level.

And unfortunately it is also a recipe for serious eating disorders. Hello anorexia.

6 comments

"bullshit", "quackery", ""healers" and witches"

Is all that really necessary?

When it comes to human health, the unknowns are legion. Medical science is in its infancy, but too many act as though it's a mature discipline built upon rock-solid theories with few problems.

20 years ago, I noticed that my mental fog cleared up and I felt healthier when I ate very low carb, I looked to pioneers like Atkins and others who predicted my results much better than those pushing the "food pyramid". Those pioneers were called "quacks". I was told over and over by supposed experts: "Calories in equals calories out.", "A calorie is just a calorie.", "You're going to ruin your kidneys on a high protein, high fat diet.", and on and on.

The problem isn't science. Science is the best method we have to discover the nature reality. The problem is with science used as a religion or political weapon without humility or appreciation of its flaws and limitations.

The food pyramid was never backed by any high quality evidence. It was primarily pushed by various agriculture lobbies.

Calories in calories out is 100% valid for weight loss. The problem is that people interpret it to somehow be a claim on overall health when it is just a statement on weight gain and loss, which while can be beneficial to health, isn't everything.

A calorie is just a calorie, so much as color is color. Its a single property of food that can be compared. If you want to lose weight that is the property you primarily need to look at. If you care about overall health then obviously there is a lot more to it than just calories. People somehow interpreted a calorie is just a calorie as a claim that all food is the same when its just saying that from a weight loss perspective, the energy component from any food source is the same -- there are no further claims about nutrition content.

"The food pyramid was never backed by any high quality evidence"

And yet medical organizations backed government efforts to force it upon our society.

"Calories in calories out is 100% valid for weight loss" "A calorie is just a calorie, so much as color is color."

Yeah, and you can tell an obese person to cut off their legs to lose weight. Sure, you'll be factually accurate, but are you honestly talking about weight loss?

"If you care about overall health then obviously there is a lot more to it than just calories."

Is weight loss without health considerations really the subject you think people discuss when they talk about weight loss? Nobody talking about actual dieting and weight loss is talking about thermodynamics. We're talking about the complex interactions between food, exercise, mental health, and our individual bodies in order to reliably lose weight and be healthier.

Actually there are well documented cases where not all calories are good and the same high sugar diet leads to more diabetes.
> "Autophagy", that famous process which supposedly happens during fasting, that miraculously regenerates us, actually happens during caloric restriction, and it's actually a daily process that happens during the night, in everyone, while glycogen stores get naturally depleted.

Last I looked into it, we didn't really know the autophagy timeline in humans, because we can't really measure it. Of course there's a natural fasting window that every human adheres to while they sleep, but with food available at all times, three meals a day plus snacks, that window may be far smaller than what the body is evolutionarily adapted to. What if autophagy doesn't kick in properly until 10, 12 or 14 hours?

Fasting isn't about starving yourself, or being malnourished. When you do eat, you should be getting plenty of calories, and eating well, not garbage.
Skipping a few days of food while being overweight (the vast majority of people in the west) won't do any of what you listed though. You're probably confusing "starving" and "fasting".
Fasting != malnourishment tho.

Anecdotally, I've been doing 16/8, 20/4 intermittent fasting and a couple of 24-48h fasts over the past 10 years and have not yet developed anorexia.

I've been doing 16/8 for the past year+ and I've barely lost any weight (BMI of 25.5ish but I'm muscular). I've always been quite comfortable going without food for 16 hours, so I'm never even hungry.
Someone recently posted a link on HN to a book by an Herbert Shelton MD that you might find interesting:

https://web.archive.org/web/20110222200902/http://www.soilan...