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by gridlockd 2104 days ago
> "Autophagy", that famous process which supposedly happens during fasting, that miraculously regenerates us, actually happens during caloric restriction, and it's actually a daily process that happens during the night, in everyone, while glycogen stores get naturally depleted.

Last I looked into it, we didn't really know the autophagy timeline in humans, because we can't really measure it. Of course there's a natural fasting window that every human adheres to while they sleep, but with food available at all times, three meals a day plus snacks, that window may be far smaller than what the body is evolutionarily adapted to. What if autophagy doesn't kick in properly until 10, 12 or 14 hours?