[hombre_fatal]

I had just come out of the peak of an acid trip so intense that I was in the fetal position under my covers. 1-2 hours had passed but it felt like an entire day. And it took me 10 minutes just to finally message my friend the profound admission: "im trippin".

I was pretty hungry after all this and glad the peak was behind me. Got a grapefruit out of the fridge. Wasn't even halfway through when I found myself back in the peak. Had to crawl back into my bed where the curtains were closed and endured another 20 minutes of that.

Grapefruit + <drug> has always been the source of superstitious arguments in uni among my drug-using friends. Does it enhance the effect? Kill the effect? Do anything at all? But my acid experience confirmed one pairing beyond all doubt.

[mayniac]

I vaguely remember grapefruits being Hunter S Thompson's favourite fruit. I don't think it was for the taste.

And your experience matches mine. Washing down MDMA with grapefruit juice definitely makes it more intense.

[htfu]

Inhibiting CYP3A4 should definitely increase LSD AUC, but it can't magically conjure more of a substance out of thin air after it's all already entered your bloodstream - only slow down breakdown. Albeit the apparent effect would be the former, if ingested beforehand and/or dealing with something with very slow uptake and high first-pass metabolism.

In any case it's not something that plays out so quickly.

Waving in and out of tripping balls a couple hours in sounds pretty par for the course, I'd say :)

[cwkoss]

Perhaps changing the ph of the bloodstream could also have an effect? Would presumably increase solubility? Lots of lore around citrus with psychedelics, seems plausible but would be nice to have more research on the mechanism.

[Scoundreller]

If the pH of your bloodstream goes out of whack enough to impact solubility, you’re long dead.

[cwkoss]

Thanks, you are right. Looks like blood pH must remain between 7.35 and 7.45 or else serious negative effects occur. Solubility change would be negligible.