[cwkoss]

Perhaps changing the ph of the bloodstream could also have an effect? Would presumably increase solubility? Lots of lore around citrus with psychedelics, seems plausible but would be nice to have more research on the mechanism.

[Scoundreller]

If the pH of your bloodstream goes out of whack enough to impact solubility, you’re long dead.

[cwkoss]

Thanks, you are right. Looks like blood pH must remain between 7.35 and 7.45 or else serious negative effects occur. Solubility change would be negligible.