[htfu]

Inhibiting CYP3A4 should definitely increase LSD AUC, but it can't magically conjure more of a substance out of thin air after it's all already entered your bloodstream - only slow down breakdown. Albeit the apparent effect would be the former, if ingested beforehand and/or dealing with something with very slow uptake and high first-pass metabolism.

In any case it's not something that plays out so quickly.

Waving in and out of tripping balls a couple hours in sounds pretty par for the course, I'd say :)

[cwkoss]

Perhaps changing the ph of the bloodstream could also have an effect? Would presumably increase solubility? Lots of lore around citrus with psychedelics, seems plausible but would be nice to have more research on the mechanism.

[Scoundreller]

If the pH of your bloodstream goes out of whack enough to impact solubility, you’re long dead.

[cwkoss]

Thanks, you are right. Looks like blood pH must remain between 7.35 and 7.45 or else serious negative effects occur. Solubility change would be negligible.