[jeremysmyth]

If someone is going to take full doses of psychedelics multiple times per week, I have no doubt in my mind that they could go through serious mental health issues.

Why? There is nothing in the report to support that viewpoint, and quite a few points that contradict it to some extent.

[ParanoidShroom]

Because you brain needs a rest from that flood of information. You'll go mad just as you'll go mad if you stop sleeping.

[semerda]

The brain is extremely active while you sleep. The brain never rests. It is always active. The question is how active is it under different situations. The brain can't tell if the information it is receiving is from a real visual experience or a psychedelic. I'm sure stress does more damage than a psychedelic experience and we experience that daily in business/startups et al.