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by jerhinesmith 4261 days ago
I'm really interested to see if the r-naught is sustainable in developed countries. This paper (http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2...) projects it as between 1.0 and 2.0 -- the nurse in Dallas makes it at least 1 for the first US case, but it could be a few more weeks to know if she was the only one.
3 comments

>Our statistical analysis of the reproduction number of EVD in West Africa has demonstrated that the continuous growth of cases from June to August 2014 signalled a major epidemic, which is in line with estimates of the Rt above 1.0. Moreover, the timing of Rt reaching levels above one is in line with a concomitant surge in cases in Sierra Leone and Liberia. In a worst-case hypothetical scenario, should the outbreak continue with recent trends, the case burden could gain an additional 77,181 to 277,124 cases by the end of 2014.

Not good. R~2 is a deeply scary figure. R1.7 is better but still wildly explosive. 1.4 puts us in run of the mill "ballooning epidemic" territory.

The best case estimates of R-naught for Africa don't have a whole lot of "best" about them.

Clearly the dataset outside Africa isn't large enough to support meaningful analysis yet. I hope it stays that way, and Africa can get its arms around this thing before it kills millions.

For others who wondered about the R-naught reference - how many people one infected person will then onwards infect.

http://en.m.wikipedia.org/wiki/Basic_reproduction_number

Measles is 12-18, Ebola 1-2. Before that makes you feel comforted, 1918 flu had r0 of 2-3.

Great.

Problem is, the data from West Africa is so bad in quality it could easily be 3 (e.g. I believe that's in line with the CDC's worst case estimate for January).

Which to echo simplemath is deeply scary.

> the nurse in Dallas makes it at least 1 for the first US case, but it could be a few more weeks to know if she was the only one.

Since it's a single case though, this is far from statistically significant. We don't know what R0 will be in the US.