That's not going to help his revenue problem, probably. The only thing I can think of is if he--in addition to making it look appealing--somehow places targeted ads based on user queries, in the midst of their search results. This is essentially the "killer" strategy a lot of companies like FB and Twitter have started using. Make ads a seamless part of the scenery. Not as annoying sidebar shit that no one ever looks at.
Depends on how he decides to monetize it I guess. But at the very least a better designed site gives the impression of professionalism and security, and users who trust you will also trust you with their money. Also a better organized (I think less noisy) site would make the ads easier to see and more relevant.
Although for me, the bigger issue is finding what Twicsy offers that's worth paying for?
It might solve the "unfundable" and "piece of shit" adjectives in the title.
pretty much the whole Internet is built on the idea that if you can get metrics like his up, and get funded, you can figure out monetization with the help of your expert investors.