[lonelyasacloud]

Lowers the protein and achieves 26% slowing of decline but unexpected decreasing cognitive benefits at higher dosage

[DANmode]

Because it’s cleaning up a symptom of Alzheimer’s (and other conditions where infections cause poor waste clearing/excess waste creation),

not reversing some known mechanism of Alzheimer’s.

[lonelyasacloud]

If it’s waste to be cleared then a plateau would be the default assumption. Degradation past a point suggests something else.

[DANmode]

That the medication is additional burden on already overwhelmed detoxification processes?

My best guess.

[lonelyasacloud]

It could be a burden. Another intriguing possibility is that the waste isn't waste, instead maybe something necessary to trigger or run some other form of protective process.