[zeckalpha]

My understanding is that they're not sure if the vaccine will last in your system for more than 30 years, and that subsequent doses may be less effective, so getting it early may weaken you later.

But I am with you. My personal bet is we'll know more about this by the time that becomes an issue.

The earliest cohorts of vaccinated children are approaching their 30s, so we should learn about long term efficacy this decade.

[robot_jesus]

It's a fair callout, but for me (and increased propensity for Alzheimer's) the calculus is a bit different. Making to to my mid-70s with full mental faculties would easily be worth the tradeoff of an increasing likelihood of shingles at that point. And besides, I would presume I would be able take the vaccine again?

[warshinder]

They have donanimab now, and apoe4 testing may qualify you if you have any prodromal (easily faked frankly) symptoms and a decent insurer.

[dualvariable]

> they're not sure if the vaccine will last in your system for more than 30 years

Vaccines don't really last in your system more than a few days (although some cells get dragged off to the lymph nodes and get harshly interrogated for longer than that). It is the T-cell and B-cell responses that are persistent for years.

> and that subsequent doses may be less effective

They should activate B cells that you already have and produce high-affinity mature antibodies.