[aucisson_masque]

> later switched to a low dose of much cheaper grey market semaglutide for maintenance.

Do you plan on staying on a 'low dose' of semaglutide Ad vitam æternam ?

I'm asking because I believe that's one of the negative of these kind of drugs, it's effective at losing weight but as soon as you stop you gain back all the weight whereas learning to eat healthy is slower but more durable.

[nwienert]

I remember I saw a meta review that claimed in the abstract that "analysis showed a rapid regain of weight after cessation of therapy", but then looking into it deeper actually quite a bit of weight loss was retained even many months after stopping.

In my personal experience I've now known about 12 people who've taken it and stopped, and none have "rapidly" regained, in fact many have retained most of their loss for significant periods of time. Most people gain weight over a long period of time (from lets say early teen to their current age).

What happens when they stop is a very slow return to baseline gain. So if it took them 10 years to become obese, then it takes 6-12 months to lose it all with Tirzepatide, you'd expect it would take them 10 years again to regain it.

People act like this is some sort of addiction, but I don't think so - and I'd bet that a "refresher" that was only a small % of the year would keep most people completely at baseline, and they could even slowly taper that down.

[toraway]

For me at least it definitely wasn't quite so abrupt, it was probably about 2.5 months before I noticed the trend line ever so slowly moving up. Pre-Zepbound I had already lost about 30 pounds from my max weight of 260ish thanks to a strict Keto diet I began at the beginning of COVID lockdowns which was a lot of effort to maintain long term, so when I saw I met the criteria for my insurance to cover Zepbound I was like "sure, why not?".

I'd probably just go back to Keto if I decided or was forced to stop a GLP-1a completely. Keto was the first and only way I've had success losing weight in my life. But once the initial novelty wears off it takes a lot of discipline to stick to and continually avoid the pressure from friends/family to eat with everyone else. I'm also vaguely concerned about cholesterol impact long term doing it for life, but relative to obesity probably still a good trade off.

It's definitely doable though, I did it for 2 years so I know the drill and that's my fallback. But not being obese is much more enjoyable than being obese, and it's a lot easier to exercise at a normal weight, so I don't have much interest in going back to 260 pounds. If that meant taking a drug for life, so be it unless it turns out to cause turbo-cancer or something.

I mostly eat "healthy" foods by preference (and habit from growing up in a "health food" family), but for me my problem is managing portion control while never feeling completely full at the target calories per meal/day. Which can feel pretty miserable to stick with especially comparing to others in my family who more or less eat the same foods but don't have that problem at all. Keto was so effective because I actually felt "full" (at the expense of excluding a lot of otherwise healthy but carb-rich foods).

Taking Zepbound definitely reshaped my perception of obesity though, compared to Keto which required constant, intense self-enforced discipline avoiding 4/5 of any menu, being on a GLP1-a and able to eat what everyone else is eating but just stop and not feel hunger pains or cravings convinced me the attitude of "fat=lacking discipline" is antiquated and ignores real variance in how different people experience hunger/satiation.

[aucisson_masque]

> Taking Zepbound definitely reshaped my perception of obesity though, compared to Keto which required constant, intense self-enforced discipline avoiding 4/5 of any menu, being on a GLP1-a and able to eat what everyone else is eating but just stop and not feel hunger pains or cravings convinced me the attitude of "fat=lacking discipline" is antiquated and ignores real variance in how different people experience hunger/satiation.

Well I always assumed that people are fat because they are eating too much...of the wrong thing.

I lost 10kg not long ago, 20 lbs in American, and never ever i did feel hungry. Quite the opposite, i would be stuffed to the nose on fruits, vegetables and meats.

And believe me when I tell you I ate like an ogre.

I challenge anyone to actually gain weight on eating only vegetable fruits and meat. After losing these 10kg, I tried to gain 15kg of muscle and overeat on this regime to the point to want to vomit, couldn't gain weight. When I added fat and cereals, weight increased so fast I had to slow down.

With the average caloric expenditure being 2200 kcal for a normal healthy man, not even doing sport, the average vegetable being 300 kcal per kg, it means you would have to eat 7.3kg (16lbs) of vegetable per day.

I don't know you personally but I can safely say that you can't eat 16 lbs of vegetable per day, or 5lbs per meal. It's physically impossible.

So yeah I guess that how people experience hunger/starvation could play a role, but it's not the full story.