[wincy]

I feel like if all the things people believe and espouse about hallucinogens were true and not just the effect of permanently damaging your mind, with the illusion of wisdom, we’d be able to point at all the revolutionary scientific breakthroughs and discoveries made under the influence of hallucinogenic substances.

However, everyone I’ve met who admits to having taken hallucinogens seems reduced in some way, rather than enhanced. Like the lights are on but someone else is home.

[LVL96]

This was sort of my experience with LSD. It just broke me. I fell into a deep depression afterward, but the reason was only partly due to damaging my mind. The other part of it was that the LSD made me realize where my life was going, and how completely unfulfilled I'd end up being in 10-20 years. In that way, it helped me course-correct. I'm healthier, more honest with myself, and got back into college because of the experience.

But it did damage my mind. I have mild to moderate anhedonia now. Weed hits me completely differently now (feels more like strong caffeine + brain fog instead of any pleasure). I lost my desire to write creatively.

[bongodongobob]

Unless you did a thumbprint, you're perfectly fine, no damage. Just get your shit together, that seems to be your takeaway. Sounds like it worked. Now you have to keep working on yourself rather than blaming a harmless drug for your problems.

[wizzwizz4]

If a thumbprint can do damage, why can't a lower dose? What's the mechanism?

[bongodongobob]

It's similar to one aspirin vs 10000. Also, people do thumbprints and live normal lives after, I just threw that out as an extreme. LSD is very safe if you're doing normal doses. Most people don't take 10000 doses so I can't really speak to that.

[InvertedRhodium]

Water will kill you if you consume too much of it - almost universally, the poison is in the dose not the substance.

[wizzwizz4]

The mechanism for water toxicity is physically displacing ions in the brain, causing osmotic damage. (This also explains why lower amounts of water are safe.) A thumbprint dose of LSD is nowhere near high enough to do something like that.

[_rpxpx]

There are lots of examples, you've just decided not to see them. Just for a start, here's an account by Ralph Abraham of the impact of psychedelics on mathematics. http://www.ralph-abraham.org/articles/MS%23124.Maps/maps2.pd...

[antonkar]

There is the Qualia Research Institute, one of the things they do is using dope and making simulations of the experience. They basically found 2 main types of drugs:

1. Most “create more separate personalities” in you

2. One (the “toad poison”) actually makes you feel like a giant place, the feeling is usually pleasant.

So there is either “agentification” of you into more “agents” or “space-ification” into one giant place without any agency in it. I think we can make this static place AI and it’ll be safe by definition because we’re the only agents in it.

P.S. I don’t promote drugs

[gruntbuggly]

A fair observation, but real assumptions about progress, what it means, and what is valuable

[ljsprague]

I don't know if he credits the drug for the inspiration but the inventor of PCR was famously a user of LSD.

[bongodongobob]

It happens all the time. DNA double helix is a good example. You really think people are going to mention their drug use in white papers? I think not. Nothing to gain and everything to lose.

[devmor]

The record of a scientific discovery that is heavily criticized for plagiarism and falsehoods is probably not a good example, actually.

[bongodongobob]

Well here's one: tons of people do drugs. It's not even a question whether or not drugs have inspired discoveries. They obviously have.

[wat10000]

Tons of people eat carrots. That doesn’t imply carrots have inspired discoveries.

[soulofmischief]

That is a textbook false equivalence.

[wat10000]

It’s exactly the same argument.

[devmor]

Have they? I find it likely, personally, but it doesn’t mean it’s not entirely coincidental either.