[NavinF]

meth vs adderall is more about dosage. If for some reason you decided to consume massive amounts of adderall the same way crazy homeless people consume meth (1000mg instead of 30mg), you could get addicted to it. Pretty much nobody does this with adderall, but the theory is solid. See https://www.astralcodexten.com/p/drug-users-use-a-lot-of-dru...

> Despite the repeated claims of METH being more addictive or preferred than AMPH, proven differences between METH and AMPH in addiction liability and in reward efficacy have evaded researchers. Animals self-administer METH and AMPH at comparable rates (Balster and Schuster 1973) and humans prefer similar doses (Martin et al. 1971). Also, neither humans nor animals discriminate between equal doses of METH and AMPH (Huang and Ho 1974; Kuhn et al. 1974; Lamb and Henningfield 1994). Furthermore, while METH is commonly believed to be a more potent central psychostimulant than AMPH, no direct comparison on the potency of the two drugs to stimulate central processes have been verified. In addition, no previous study has directly compared the acute effects of the two drugs on locomotor activity, an important central process that contributes tothe definition of psychostimulant. Moreover, there are no known neurobiological differences in action between METH and AMPH that would account for the putatively greater addictive, rewarding, or psychomotor properties of METH.

[SanDiegoSun]

> The psychostimulants d-amphetamine (AMPH) and methamphetamine (METH) release excess dopamine (DA) into the synaptic clefts of dopaminergic neurons. Abnormal DA release is thought to occur by reverse transport through the DA transporter (DAT), and it is believed to underlie the severe behavioral effects of these drugs. Here we compare structurally similar AMPH and METH on DAT function in a heterologous expression system and in an animal model. In the in vitro expression system, DAT-mediated whole-cell currents were greater for METH stimulation than for AMPH. At the same voltage and concentration, METH released five times more DA than AMPH and did so at physiological membrane potentials. At maximally effective concentrations, METH released twice as much [Ca2+]i from internal stores compared with AMPH. [Ca2+]i responses to both drugs were independent of membrane voltage but inhibited by DAT antagonists.

Do you intentionally cite way out of date scientific research? What is your background in pharmacology? The simple addition of the methyl group is known to effect absorption and potency.

[NavinF]

1. Why make claims about 5x dopamine and 2x Ca2+ instead of just scoring how people respond to the drug at various dosage?

2. None of that is relevant. I'm talking about people taking >30x the dose, not 5x lol. Do you have a background in pharmacology and not understand how that would make a difference?

[SanDiegoSun]

Your source claimed no provable increase in potency. This refutes that.

Of course a higher dosage of a more potent drug will lead to wildly different and markedly increased effects... I think you have your argument wrapped in semantic reasoning rather than pharmacology.

Beyond this, do you admit your premise is flawed?