[SanDiegoSun]

> The psychostimulants d-amphetamine (AMPH) and methamphetamine (METH) release excess dopamine (DA) into the synaptic clefts of dopaminergic neurons. Abnormal DA release is thought to occur by reverse transport through the DA transporter (DAT), and it is believed to underlie the severe behavioral effects of these drugs. Here we compare structurally similar AMPH and METH on DAT function in a heterologous expression system and in an animal model. In the in vitro expression system, DAT-mediated whole-cell currents were greater for METH stimulation than for AMPH. At the same voltage and concentration, METH released five times more DA than AMPH and did so at physiological membrane potentials. At maximally effective concentrations, METH released twice as much [Ca2+]i from internal stores compared with AMPH. [Ca2+]i responses to both drugs were independent of membrane voltage but inhibited by DAT antagonists.

Do you intentionally cite way out of date scientific research? What is your background in pharmacology? The simple addition of the methyl group is known to effect absorption and potency.

[NavinF]

1. Why make claims about 5x dopamine and 2x Ca2+ instead of just scoring how people respond to the drug at various dosage?

2. None of that is relevant. I'm talking about people taking >30x the dose, not 5x lol. Do you have a background in pharmacology and not understand how that would make a difference?

[SanDiegoSun]

Your source claimed no provable increase in potency. This refutes that.

Of course a higher dosage of a more potent drug will lead to wildly different and markedly increased effects... I think you have your argument wrapped in semantic reasoning rather than pharmacology.

Beyond this, do you admit your premise is flawed?