Yes. Not so much at the time when some margarines had trans fats in, but now? Yes, absolutely. The evidence suggests that doing so significantly reduces one's risk of CVD.
The first study is saying that it's good to replace butter with either PUFA margarine or TFA margarine. Since we already know from other places that TFAs are actually quite harmful, we know to ignore this study.
We should also learn from history that replacing our diets based on "nutritional science" has generally been unlikely to yield good health results, as long as we're not already obese. For example, nutritional science kept recommending replacing SFA with any UFA, and ended up killing many, many people because it didn't know that trans unsaturated fatty acids are actually worse than SFAs for overall health.
We can reasonably expect that similar things will be discovered in the future about other parts of margarine, and that eating traditional foods with a long history of safe human consumption is a much safer path, be they olive oil or butter or lard.
It doesn’t say good, it shows it reduces LDL cholesterol. Since the mechanism by which TFA increases CVD risk is separate to this, this is compatible with TFAs causing harm. So no reason to ignore the study, it’s making no false claims. PUFA reduces LDL-c by a greater degree and there are no known issues like there are with TFA, so substituting SFA for PUFA seems like a no-brainer.
As for nutrition science and its effect on health, just because one intervention had deleterious effects doesn’t mean that you can claim that the net effect of nutrition science on health has been net negative. Again, see no reason to believe that without actual evidence supporting it.
Nutrition science told us that we should start fortifying flour to prevent some horrendous diseases, and the net result of that has been far greater than the problems caused by trans fat consumption, for example.
I see no reason to believe that traditional foods are safer than novel foods. In fact, provided both are equally health promoting during the reproductive window, then it’s more likely that a given novel food is better for longevity than a traditional one.
> Since the mechanism by which TFA increases CVD risk is separate to this, this is compatible with TFAs causing harm.
As far as I know, the main mechanism for that is reduction of HDL-c. However, the study you cite found no reduction of HDL-C from TFA substitution.
> PUFA reduces LDL-c by a greater degree and there are no known issues like there are with TFA, so substituting SFA for PUFA seems like a no-brainer.
Key word being "known issues". One of the major issues with nutrition science is this grouping of vastly different foods based on a single simple category of substance. There are a lot of different PUFAs, and even more different specific oils or fat solids containing PUFAs, and there is no reason to believe that they are completely interchangeable in our nutrition. UFAs were once thought to be the same, before the important distinction between PUFAs and TFAs (and the still unclear position of non-TFA MUFAs) was discovered and recognized.
> As for nutrition science and its effect on health, just because one intervention had deleterious effects doesn’t mean that you can claim that the net effect of nutrition science on health has been net negative. Again, see no reason to believe that without actual evidence supporting it.
Yes, some basic findings in nutrition science did improve things worldwide health. The discovery of vitamins and various other micronutrients was by far the most important. The discovery of dietary fiber and its roles allowed nutrition science to course correct a number of bad recommendations from the earlier era. In very specialized fields, such as high performance athletes, it also show reproducible, predictable results (though not necessarily on long-term health, just measured by competition success).
> I see no reason to believe that traditional foods are safer than novel foods. In fact, provided both are equally health promoting during the reproductive window, then it’s more likely that a given novel food is better for longevity than a traditional one.
Traditional foods have an extremely long history behind them of not being acutely harmful to at least one particular population, with traditionally passed on limits of safe amounts of consumption and safe methods of preparation. They have been consumed by populations that lived with much reduced medical care than today, so they are known to be resilient even in the absence of medical interventions, which often confound nutritional studies, especially in older adults. They are also much more likely to be well adapted to the particular genetics of a certain population, unlike nutritional advice which is almost entirely "universal".
One of the main sources of nutritional discoveries has in fact been the study of traditional diets. From vitamins to fiber to fermented foods' effects on gut microbiota, the discovery has always come from trying to understand why a particular population is thriving nutritionally.
The main drawback of traditional foods is that the mechanism for passing down information on safe preparation and consumption was informal, and can be easily lost. They also tend to be hard to create industrially, so they are likely to be much harder or more expensive to consume compared to modern industrial food products. However, for people who can afford it, they are by far the better option compared to the uncertainty and contradictions of modern nutritional advice.
[Note: this is the same account as tsimiones, I'm not trying to hide behind some new name, it's just related to some software on my work PC]
That first study is -tiny- study which is a good data point but hardly worth changing my diet over. I’ve seen plenty of studies saying that butter in moderate usage is just fine, and the war on saturated fats really should have been limited to hydrogenated oils/margarine
How about a pooled analysis of 350,000 participants suggesting that for every 5% energy in the form of saturated fat that’s replaced with PUFA (like you find in margarine), the risk of coronary mortality drops by 26%.
Surely that’s both a large enough cohort and a large enough effect size to change one’s diet?
This study contradicts another study you were citing in this thread . This one says that replacing SFAs with carbohydrates is a net negative, you have to replace SFAs with PUFAs. The other study was saying that replacing SFAs with either carbohydrates or PUFAs is just as good.
It's almost as if all of these studies are looking at tiny effects that they can't adequately measure, and contradicting each other.
Not a big proponent of saturated fats but dietary LDL has only a modest impact on LDL-c - 5-10%. Other things that have similar or larger impact are exercise, reducing sugar intake, not being overweight, and consuming soluble fibre. Plant sterols/stanols also help
Problem in the 70s was trans fats. Now they're no longer a risk, replacing butter with margarine is a solid evidence-based decision for one's health (though not so much for one's enjoyment!).
Okay, the cereal commercials in the 1980s: they would have some ridiculous cartoon mascot and sing a catchy jingle about their sugary cereal treats, and then at the end, they were legally required to say "Part of this balanced breakfast" while displaying a tray laden with fresh fruit, buttered toast, perhaps a glass of orange juice.
Those commercials played multiple times a day in my childhood, and they never failed to piss me off, because they clearly demonstrated that "milk and a box of Chex" was not by any means a "balanced breakfast".