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by nordsieck 605 days ago
> With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.

So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. And while I'll be the first to admit that the proportion of people who could benefit from these drugs is quite large, it's pretty far from everyone.
1 comments
Someone1234 605 days ago
> So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight.

It is licensed, tested, and sold as a Type-2 Diabetes medication. Are you claiming it is ineffective for that purpose? Or if you're under the impression that no healthy weight T2 Diabetics exist, I have some news for you...

It is also being studied for: opioid addiction, alcoholism, Alzheimer's/Parkinson’s, Cardiovascular Disease, NASH, and PCOS.

"So far, I haven't seen evidence" may be more related to what you have read than what is available for you to read.

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jewayne 605 days ago
Don't dismiss the most important question -- does semaglutide really have any effects outside its current intended use for diabetes and weight loss?

In other words, would a thin, metabolically healthy person benefit from taking semaglutide?

So far, all of the wonderful benefits from taking the drug seem to be explainable by reduced caloric intake / weight loss / better glucose control in overweight and/or diabetic people.

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Someone1234 605 days ago
> In other words, would a thin, metabolically healthy person benefit from taking semaglutide?

That's what this thread is about; and multiple other studies looking at different diseases/illnesses/addictions. Time will tell. It is currently approved for T2 Diabetes and Obesity.

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jewayne 605 days ago
There's also the intriguing possibility that many other diseases and even addictions have a heretofore-unknown metabolic component. The idea of some addictions -- even to things like heroin or gambling -- being partially metabolic does not seem far-fetched to me.
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