[GuB-42]

When you don't know what a psychedelic experience is, any mind altering substance could do. For someone who never got drunk, it could even include alcohol.

It is very hard to describe in words what a psychedelic experience is, so without a reference point, it is hard to tell if what you experienced is one or not.

[franga2000]

Ok but now you're not comparing drug vs no drug but drug vs other drug. Yes it can be blind, but it's a cometely different study now

[GuB-42]

Suggestion alone can make you feel high. I remember someone telling me that he got high just by touching sweaty people in a music festival where most people were high, clearly, that's placebo. And that guy was far from drug-naive.

And they sometimes give active substances to the control arm to have an effect. I remember in a covid vaccine trial, they gave the meningitis vaccine to the control group to mimic the side effects of the covid vaccine they tried. Here, they actually gave a microdose of psilocybin (1mg) to the SSRI arm. I don't know why, but maybe it was enough for them to feel something without having the full effect.

[idunnoman1222]

Is alcohol the best you could do? I have a feeling that alcohol can definitely help with depression Probably one of the oldest drugs used in that regard

of course there aren’t actually that many drugs.. you clearly couldn’t give another tryptamine they are kindof all the same. I guess you could give a phenethylamine but obviously those are probably good at treating depression too so your studies gone to shit I suppose you could give a deliriant but that just sounds mean.