[Mistletoe]

> The studies - part of the Select trial - tracked more than 17,600 people, aged 45 or older, as they were given either 2.4 mg of semaglutide or a placebo for more than three years. Participants were obese or overweight and had cardiovascular disease but not diabetes.

Exciting stuff. What does data look like in people that aren’t obese?

[smt88]

Calorie restriction is a well-studied (though not terribly healthy) way to slow aging. It's likely these drugs are just making it easier for people.

[kiba]

Calories restriction worked in a wide variety of species but was inconclusive in monkeys and was never proven in humans.

[smt88]

I'm not sure what standard you're using for "proven," but there are a lot of studies showing results similar to this one: https://www.publichealth.columbia.edu/news/calorie-restricti...

There don't seem to be any huge, long-term studies, but here is a review of what's available as of a few years ago: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468870/

[rendaw]

I thought calorie restriction was another order of magnitude, beyond "normal" weight. But I guess if obesity was causing accelerated ageing, you could say not being obese is delaying ageing.

[smt88]

It varies from study to study, but generally what I've seen for anti-aging is ~1,000 calories per day or less. I've seen it as low as 500.

[woleium]

See Roy Walford et al out of UCLA on the CRON diet. Its not a nice way to live, but it seems to be safe and healthy.

[smt88]

I'll have to look into it more, but from what I've seen, it seemed that people had to restrict calories so much that their immune system was underactive (which may be a large part of why it works).

[woleium]

Interesting, i last looked at this over 10 years ago, i assume this came to light more recently than that.

[hooo]

This is a good question- I’m not sure why you’re down voted.

[7speter]

Will the non-obese people be subject to gastroparesis and all that entails?

[wmf]

I don't think this should be downvoted. For overweight people, the benefits of these drugs exceed the risks of side effects, but for healthy people there may be no benefits.