[tkirby]

Get vim/emacs and learn it inside out so you do a minimum of mousing and keystrokes. Also learn to code in your head as much as possible and only sit down at the computer to dictate your design. This is surprisingly effective once you get the hang of it. I spend about 60% less time in front of the computer now and I'm way more productive. Also get something like StayFocusd for your browser and add in all your distraction sites. If you have downtime while compiling or whatever, get away from the computer and rest your eyes/hands.

[siege]

Emacs with its shortcuts is actually a major wrist-killer - just see what happened to RMS...

(disclaimer: I absolutely love emacs, but had to switch to vim just because of strain it puts on my wrists)

[baddox]

I've only been using Emacs as my exclusive editor for about 3 years, but with my Caps Lock key set as my primary Ctrl key I've never noticed any stress or pain.

[m0tive]

vim + pentadactyl[1] + vsvim[2] have saved me from having to use the mouse for most of the work I do.

[1] http://5digits.org/pentadactyl/index

[2] http://visualstudiogallery.msdn.microsoft.com/59ca71b3-a4a3-...