[corry]

Curious if someone more familiar with this space could comment on what exactly is meant when it says the drug in question -- MM120 -- has been "pharmacologically optimized" from the base LSD?

I know the "real" vs "synthetic" distinction is kind of silly w.r.t. psychedelics in general (especially so with LSD since it's only ever been synthetic), but understanding exactly how the new crop of drugs actually differ from the usual suspects would be helpful in evaluating to what degree this is 'just' a business move to offer something proprietary and corner the market vs. it's legitimately better for patients.

That said, I believe the biggest drawback with using LSD in a clinical or therapeutic setting is the length of the experience (12+ hours), so a tweak around shorter duration would make more sense to me.

[ProjectArcturis]

MM120 is chemically identical to LSD. The "optimization" they claim is just a regulatory workaround aimed at maintaining patent protection for longer.

As far as shorter trips, Compass Pathways is testing psilocybin for depression. Another company, Field Trip Health, was developing an analog of psilocybin with a shorter trip duration, but it doesn't seem to be progressing past Phase 1 trials.

[Jerrrry]

All lysergamides are nearly indistinguishable.

The only reason this exists is because all the other easily modifications and analogs have already been tainted legally.

"Orange sunshine"/ AL-LAD / 1pLSD / LSZ, they are all the same bicycle ride once it hits your tongue.

This is just a patent/legal facilitation.

An exiting one, none the less. :)

[valec]

it's more accurate to characterize LSD as semi-synthetic, just like thebaine derivatives such as hydrocodone, hydromorphone, and oxycodone. it's a simple one or two step transformation from ergot-derived alkaloids.

it seems like MM120 is literally just the "optimal dose" of the tartate salt (the normal salt LSD is co-crystallized with) of LSD in a pill. it doesn't seem like there's any special delivery device, nor is it any sort of prodrug nor is it a deuterated analogue.