[kortex]

> Although initial investigations reported the negative effect of ROS, recent studies have shown that exercise-induced ROS can upregulate several enzymatic and nonenzymatic antioxidants in the biological system [7, 8], and exercise could be an optimizer of ROS in negating oxidative damage in the cells, while ROS can regulate signaling or act as a signaling molecule to muscular adaption.

Did you even read your own link, or are you just googling keywords and linking papers with a title that superficially supports your thesis?

[Podgajski]

Yes I did, thank you for continuing the conversation.

Those enzymes that it unregulated, those genes that they upregulate… do you know what they are? Let’s talk about one…mnSOD or SOD2.

Do you know that enzyme needs a co-factor and that co-factor is manganese. What do you think happens when you keep exercising, but do not replenish your manganese? mnSOD does not work as fast and this leads to a buildup of superoxides and disease.

Up regulating these enzymes because we’re exercising is not decreasing oxidative stress, it’s getting rid of the oxidative stress that we created. And all that results is that we deplete ourselves in manganese.

Does this happen for everyone? No does this happen for people who might have polymorphisms in there SOD2 genetics? Probably.

https://journals.physiology.org/doi/full/10.1152/ajpcell.003...

[kortex]

Ok, so make sure you get enough dietary manganese?

RDA for Mn is 1.8-2.3 mg/day. Tolerable upper limit is 11mg/day. Mn ions are highly conserved in the body and mostly cycle through redox states and various complexes.

That's actually a pretty narrow therapeutic window, again because it's a trace mineral and biology has evolved to recycle it very efficiently.

[Podgajski]

Yeah, that’s what I thought until I had my hair and serum levels of manganese tested. Which were both low. And taking manganese cured not only my chronic fatigue, but my insomnia and anxiety as well.

Also, there’s a study at Stamford going on right now, looking at manganese levels and illness and they’re finding that these ranges are old and arbitrary.

And that tolerable upper limit is a joke since I had to take 30 mg a day.

Just do a little research and find out where they got those limits and ranges from.

But, regardless, it proves my point, that exercise depletes manganese and that could cause disease in people who don’t have sufficient manganese. So just telling everyone to work out and you’ll live longer is a false statement.

Adding

https://www.efsa.europa.eu/en/efsajournal/pub/3419

There are no reliable and validated biomarkers of manganese intake or status and data on manganese intakes versus health outcomes are not available for DRVs for manganese. As there is insufficient evidence available to derive an average requirement or a population reference intake, an Adequate Intake (AI) is proposed.