[ramraj07]

For anyone even remotely interested in learning how research happens and how research should happen if it happens well, you should listen to the Peter Attia podcast with Richard Miller who runs the ITP program mentioned here. It’s definitely the most thoughtful research program that I can think of that’s currently running. https://peterattiamd.com/richardmiller/

Having said that Acarbose was still only shown to extend life in mice. The moment something is about gut microbiome I start losing confidence in the ability of mouse models in predicting human behavior.

When I originally heard about Acarbose in this episode I looked up Reddit as I usually do and the scant mentions all recalled smelly flatulence as a gross side effect. Take that for what you want! Not to mention it worked only in male mice and we have no idea how! This is not confidence inducing especially if you’re committing to becoming horrendously smelly!

[JumpCrisscross]

> it worked only in male mice

There are multiple studies. The larger ones seem to find it working in female mice, too [1].

[1] https://pubmed.ncbi.nlm.nih.gov/30688027/

[ramraj07]

Sure but the discrepancy is too Much, suggesting a hormonal component. Which is all the more confusing since this blog post (leaving aside its preachiness) was about gut microbiome based efficacy. Thus the efficacy of this drug is validated in mice while its mechanisms is incontrovertibly spread along two dimensions I wouldn’t even individually trust to translate well from mice to humans, leave alone synergistically.