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by JumpCrisscross 1007 days ago
> it worked only in male mice

There are multiple studies. The larger ones seem to find it working in female mice, too [1].

[1] https://pubmed.ncbi.nlm.nih.gov/30688027/

1 comments

Sure but the discrepancy is too Much, suggesting a hormonal component. Which is all the more confusing since this blog post (leaving aside its preachiness) was about gut microbiome based efficacy. Thus the efficacy of this drug is validated in mice while its mechanisms is incontrovertibly spread along two dimensions I wouldn’t even individually trust to translate well from mice to humans, leave alone synergistically.