[Aurornis]

The study used a mouse model where amphetamine is used to simulate schizophrenia. Obviously, it's not guaranteed to map to real humans having real schizophrenia.

That doesn't mean it's a useless result, but everyone should remember that research is an accumulation of decades of many little pieces of information. This is another clue, not a "nail in the coffin" of old theories.

The ultimate evaluation of medication is how well it actually performs in studies. If someone can develop a new medication that is more selective for D1 and show that it performs better and/or has fewer side effects then this would be a great result.

However, don't get too excited. The pharmaceutical industry is often 10 steps ahead of public findings like this. A selective D1/D5 antagonist with negligible D2 affinity has already been trialed for schizophrenia without good results: https://en.wikipedia.org/wiki/Ecopipam

Many of the most prescribed schizophrenia medications already have significant D1 affinity, too, so it's not really correct to say that we're "off target"

These findings tend to be very aggravating to computer scientists who are familiar with systems that (mostly) obey clear-cut rules and can examined in extremely fine detail with enough equipment and motivation. Neuroscience is not so simple, but that doesn't mean it's all wrong. Each finding is one more piece of the puzzle.

[fragmede]

While everyone should be keenly aware the limitations of taking experimental results in mice and extrapolating to humans (aka, they often don't), doesn't that mean what we really have, is a bunch of well tested medication for meth addicts? Which; if there was a way to get meth addicts off meth, would be a boon?

[edgyquant]

Not necessarily addicts. You don’t have to be addicted to achieve psychosis you just need to take a certain amount. For me this amount is pretty small, I was prescribed adderal for awhile and even 20mg was enough to induce serious paranoia and the occasional hallucination

[freeone3000]

This wasn’t tested and wasn’t purported to test countering either addiction or acute overdose. This is a study showing the method of action. In mice (and humans, D2 receptor agonists are not new drugs), we have a method of countering the psychosis effect of meth. This has some value in ER and rehab settings where it is currently for healthcare provider safety; there is no evidence that it does anything else.

[monknomo]

It's not for addiction, but yes, if someone takes enough meth to induce psychosis, antipsychotics will reduce the psychosis.

[chrsig]

To be fair, there is a meth problem in the US.

Also there's a huge chasm between lab grade amphetamine and street meth.