[smokeydoe]

This is very defensive. Of course they are effective, but there are very few studies on the long term effects. Common sense says that dosing your body with neurotoxic amphetamines over a long period is not good for your central nervous system. Take it everyday if you want, but don't pretend to know about the safety of long term use.

The drugs own warnings are pretty bad: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f22...

[edrxty]

There's very little evidence it causes any problems. Some of these medications have been in use since the 60s and most have at least 20 years of data behind them.

>neurotoxic amphetamines

That's deliberately loaded terminology. Amphetamines are neurotoxic but not at the doses used therapeutically (obviously). Everything is neurotoxic at a high enough dose.

>The drugs own warnings are pretty bad

All drugs have pretty bad warnings:

Each year, the side effects of long-term NSAID use cause nearly 103,000 hospitalizations and 16,500 deaths. More people die each year from NSAIDs-related complications than from AIDS and cervical cancer in the United States.

https://www.sciencedaily.com/releases/2005/01/050111123706.h...