[GoldenRacer]

For context on what an appropriate dose is, this article seems to suggest that the intensity of most effects start to flatten out as you go past 100ug. The effects that continue to get more pronounced past that level seem to be negative effects such as anxiety or potentially difficult to navigate such as disembodiment.

Seems like 100ug is likely a sweet spot for most first timers.

[_proofs]

i do not know if i would actually agree with this as general advice, even for first timers (assuming healthy and safe settings) -- Strassman [0], paraphrasing as it has been a while, mentions in his findings the difference between psychotic and psychedelic thresholds. psychotic thresholds ~<= 300 mcgs tend to be more stimulant-like with an increased heart rate, and it is my opinion he contends this can be more anxiety inducing than a psychedelic dose, which depresses breathing and eases the heart rate/is less stimulating.

my anec-data is most people taking small doses, while enjoyable, seem to experience more anxiety overall than those who have taken a little more of a plunge (myself included in this) -- increased heart rate can really send people through some weird feedback loops, especially on peak.

perhaps mileage varies.

[0]: Dr. Rick Strassman, DMT: The Spirit Molecule -> this is mostly a clinical study on the effects of DMT but Strassman does have general observational commentary on psychedelics such as LSD.

[Diederich]

I agree that 100 is a good starting point, or even less.