[upsidesinclude]

This is a very suspicious statement for anyone unfamiliar with ketamine and it is exactly the type of text one would expect from a pharmaceutical company.

It is also coming from a throwaway account, so please take "the same dose was less effective" with a grain of salt.

I know many people with depression and anxiety that used ketamine and never experienced this type of response: extremely limited use and immediate reduction in effectiveness.

I don't buy it.

Edit: Initial studies show even microdoses of ketamine can cause immediate and lasting (+2 weeks) reduction in depression and anxiety. One should not be going into a "k hole" which is regarded as somewhat of an overdose even to partiers

[ketaway]

I disagree. The above is actually a (perhaps unwitting) story of what to avoid in ketamine treatment.

My experience is that I dislike the feeling of ketamine high, and I use a small dose fortnightly. If I go longer than that, the depression and suicidal ideation return. I use a small enough dose that I do not feel the immediate effect. It takes a day or three before I experience a reduction in depression and suicidal ideation, but after that, the part of my brain that says "kill yourself" every few minutes goes completely silent.

I also know people who seek out the k-hole and have built up ridiculous (and very expensive) tolerance to the drug. Their stories are very similar to GP. To be avoided.

[upsidesinclude]

I appreciate your input and it helps to clarify my point as well.

I believe we agree on most everything else if not our perception of the poster.

[kthrowaway]

I dunno what to tell you. I will say that I have also been prescribed multiple antidepressants (Sertraline, Lexapro, fluoxetine, wellbutrin) and I stopped them all because I hated the side effects, so pharmaceutical companies haven't been any help to me either. That's why I was so initially interested in the potential in ketamine as a treatment. If it works for you, more power to ya. I have a friend who goes in for regular infusions and says it's better than any antidepressant she's ever been prescribed.

[qnt5]

Ketamine not only saved my life, it saved my marriage, and my job. I had a mental breakdown. Went catatonic while at work from life/work stress and 13 years of 80 hour weeks. I was able to take a six month leave from work, and had been on all different anti-depressants/anti-anxiety meds for 10 years. A mix of ketamine, time away from work, and therapy quite literally saved me. It's crucial to understand that everyone's mileage may vary, as with every medication/treatment.

[in3d]

You’re making unsupported assertions. It is unclear how dose-dependent the therapeutic effects are. I definitely haven’t seen anything to suggest that microdoses can work as well as larger doses.

[upsidesinclude]

You are making inference & unsupported assertions.

Please feel free to investigate and provide educated feedback