[thebeastie]

What does that mean, preventing stress adaptations? Does it mean that the body wouldn’t get stronger in training ?

[nradov]

Right. Some of these potential longevity interventions seem to have a catabolic effect. Not a problem if you're a mouse living in a safe, flat lab cage. But problematic for an elderly human at risk of falling down the stairs and breaking a hip due to sarcopenia.

[eternityforest]

Is it strong enough to actually cause that, or is it the kind of thing nonathletes won't notice?

Or is the life extension effect too subtle to be relevant at all outside a flat mousecage?

[nradov]

It's just a general trend. The strength of the catabolic effect will depend on the specific intervention and dose. The risk is greatest for non-athletes because they tend to be weaker to start with and more likely to experience disabling falls as they age.

[elevaet]

That is really interesting. I hadn't heard that, but it makes a lot of sense.