[eternityforest]

Is it strong enough to actually cause that, or is it the kind of thing nonathletes won't notice?

Or is the life extension effect too subtle to be relevant at all outside a flat mousecage?

[nradov]

It's just a general trend. The strength of the catabolic effect will depend on the specific intervention and dose. The risk is greatest for non-athletes because they tend to be weaker to start with and more likely to experience disabling falls as they age.