Probably fine for small-scale use, but on a planetary scale increased salinity could dramatically influence marine biodiversity, not to mention climate from thermohaline circulation disruption [1]
It's not possible to change ocean salinity by any measurable amount by desalination. Except maybe for some very closed off seas, which are already less saline than the ocean.
It is in the water cycle anyway, so yes globally really makes no difference. But the localized levels of salinity certainly can be effected and be detrimental.