It's not possible to change ocean salinity by any measurable amount by desalination. Except maybe for some very closed off seas, which are already less saline than the ocean.
It is in the water cycle anyway, so yes globally really makes no difference. But the localized levels of salinity certainly can be effected and be detrimental.
Total US water usage is about 2 cubic miles per week - which is not even a 100 millionth of the water in the ocean.