[FollowingTheDao]

> The main effect of tofizopam is unrelated to GABAergy

It's a antagonist of the AMPA receptor. I am not saying it has anything to do with GABA-A but it enhances the action of GABA.

https://www.nature.com/articles/nn0600_551

>By taking a classical benzo like klonopin you increase your GABA-A level which inhibit the overload of excitation (GLUT).

No, Klonopin does not increase GABA, it attaches to the GABA-A receptor to allow more chloride into the cell. It only enhances the activity go GABA.

https://en.wikipedia.org/wiki/Clonazepam#Pharmacology

[The_rationalist]

I have not found information saying that tofisopam is an AMPA antagonist. But you are probably right, the answer must be on the paper you link I guess. Nevertheless the action on PDEs is what makes tofisopam unique.

> No, Klonopin does not increase GABA Yeah that's right. GABA releasing agent, GABA reuptake inhibitor and GABA transaminase inhibitors do exists but benzos have not those properties. They are GABA-A positive allosteric modulators (they are not agonists although GABA agonists do exist too). So yeah they potentiate GABA functionally without increasing its quantity directly.