[The_rationalist]

I have not found information saying that tofisopam is an AMPA antagonist. But you are probably right, the answer must be on the paper you link I guess. Nevertheless the action on PDEs is what makes tofisopam unique.

> No, Klonopin does not increase GABA Yeah that's right. GABA releasing agent, GABA reuptake inhibitor and GABA transaminase inhibitors do exists but benzos have not those properties. They are GABA-A positive allosteric modulators (they are not agonists although GABA agonists do exist too). So yeah they potentiate GABA functionally without increasing its quantity directly.