others I haven't seen. But I'm talking of different thing. What is absent in modern game are the attempts of synthesis of different genres, which were frequent in 80s or 90s, and gave us such gems as Dune 1 and Star Control 2.
Binding of isaac is arguably an action RPG mixed with rougelike, both were developed genres before it was made, it was a synthesis of both. It helped launch the rougelite genre/achetype.
What about binding of Isaac?
I've heard that noitka is pretty blendy
Minecraft launched a new genre
Auto chess is a new genre that came out recently