others I haven't seen. But I'm talking of different thing. What is absent in modern game are the attempts of synthesis of different genres, which were frequent in 80s or 90s, and gave us such gems as Dune 1 and Star Control 2.
Binding of isaac is arguably an action RPG mixed with rougelike, both were developed genres before it was made, it was a synthesis of both. It helped launch the rougelite genre/achetype.
Binding of Isaak - action shooter
others I haven't seen. But I'm talking of different thing. What is absent in modern game are the attempts of synthesis of different genres, which were frequent in 80s or 90s, and gave us such gems as Dune 1 and Star Control 2.