[gizmondo]

Safety - yes, do we really need efficacy trials for such a change? Is it remotely likely to be worse?

[oppositelock]

Nobody knows until you test. Biology is messy, it's not like computers.

Give this a read, Immunology Is Where Intuition Goes To Die. (https://www.theatlantic.com/health/archive/2020/08/covid-19-...)

[gizmondo]

I happened to read it already.

Are you willing to bet that the tweaked Moderna vaccine (the trials of it was announced, right?) shows worse efficacy than the original? Odds 51:49 in your favor, null hypothesis of the same efficacy is a tie. That's generous I think, if nobody knows.

If not - why not?

[Zpalmtree]

Are you arguing we should just assume the new changes are good and roll them out without testing?

[gizmondo]

Yes, without large scale randomized efficacy trials. That's what we do with the flu.