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by javagram 1744 days ago
> I’m getting a little tired of articles or chats with people where you get the impression that people think the vaccines will create some sort of covid-proof bubble around them. This is the only explanation I can find for people acting surprised that vaccinated people get sick.

No, it’s because until the Delta variant became the most common variant, the vaccines essentially did create a covid-proof bubble around the recipient. The trials for Comirnaty and the Moderna vaccine both showed >90% effectiveness against PCR positive infections, not just against hospitalization and death.
1 comments
jrochkind1 1744 days ago
> The trials for Comirnaty and the Moderna vaccine both showed >90% effectiveness against PCR positive infections

I don't believe the official trials for Moderna and Pfizer measured PCR positive infections at all. (They involved thousands of people, it was a time when PCR test were difficult to obtain; they remain expensive at that scale).

I have not heard of Comirnaty, not sure about that.

There may have been pre-delta studies that showed PCR infection effectiveness (Cite?), I don't think they were the official trials.

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javagram 1744 days ago
Comirnaty is the brand name of the Pfizer vaccine.

According to this article, all of the major vaccine trials studied PCR positivity, not deaths/hospitalizations. https://www.bmj.com/content/bmj/371/bmj.m4058.full.pdf

> The first question is whether the right endpoints are being studied. Contrary to prevailing assumptions (including those of a former Food and Drug Administration commissioner8), none of the vaccine trials are designed to detect a significant reduction in hospital admissions, admission to intensive care, or death.9 Rather than studying severe disease, these mega-trials all set a primary endpoint of symptomatic covid-19 of essentially any severity: a laboratory positive result plus mild symptoms such as cough and fever count as outcome events (table 1).

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jrochkind1 1744 days ago
Ah, thanks for the correction.

"a laboratory positive result plus mild symptoms" was the thing being measured, ok.

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