I don’t dispute it is one point of suspicion, but Wuhan is also one of the 10 biggest cities in China. It isn’t a surprise the first US outbreak was in the biggest city. The first cases could have been anywhere.
If there were more evidence that it was lab made then the location would be another point, not to me without further evidence it doesn’t mean all that much.
And there have been 2 emerging coronavirus outbreaks in the last 20 years due to natural origin. Why is it so hard to believe there would be another one.
> I don’t dispute it is one point of suspicion, but Wuhan is also one of the 10 biggest cities in China. It isn’t a surprise the first US outbreak was in the biggest city. The first cases could have been anywhere.
Is that really so for animal-borne viruses though? I thought they came from place with lots of animals, hence the focus on the market. If it just showed up on some random high-rise employee downtown that would be hard to believe.
And after it starts, of course a highly-infectious virus shows up at densely populated places quickly. But for the same reason, I would also think it's hard for the first cases to travel to dense areas and spread the disease there without leaving a trail of cases along the trip. Ultimately they should point back to the animals they came from and testing can confirm it. Or at least rule various places out, if the govt was accommodating.
Plus wasn't the first US case somewhere in Washington state.
The first death in the U.S. was only discovered at least a month later, and this is long after we knew about the existence of the virus.
In China before there was a huge outbreak there is absolutely no way you can expect a small number of cases of a virus that nobody knows exists to be picked up. By the time of the big Wuhan outbreak there are already different variations in the virus. It had been in some population for a while before it broke out.
So the first outbreak in NYC is analogous to Wuhan. It could have started in Wuhan or it could have started anywhere else and then Wuhan had the right combination of factors for the outbreak to surge. We don’t know for sure.
We do know for sure that it started in Wuhan. The viral phylogeny is extremely clear. We have hundreds of thousands of viral sequences that describe a tree that is rooted in Wuhan around October 2019. That's incontrovertible. No evidence has arisen to contradict this despite an extensive search by thousands of scientists.
>There are two subclusters of A which are distinguished by the synonymous mutation T29095C. In the T-allele subcluster, four Chinese individuals (from the southern coastal Chinese province of Guangdong)
This reply only makes sense if covid-19 popped up at a random spot in Wuhan....and not literally right next to their coronavirus research lab.
It's not hard to believe that there could be another spillover event, and I don't have any certainty where covid-19 came from, but you're unfairly downplaying the level of circumferential evidence that does exist. There has been a significant effort against evaluating the lab-leak as a reasonable hypothesis (I say that in the scientific meaning of the word), and that effort has significantly damaged the reputation of scientific institutions around the world, and for good reason.
Yes I have read more than the articles, which is why I’m correctly saying it was unlikely to come from the lab.
I’m not saying it is impossible, just unlikely. And automatically degrading the opinions of experts who have detailed their arguments because you think they are biased is not proof of anything either.
Other pertinent data point, how many epidemics have been positively traced to a lab leak since virology has been widely studied? The Wuhan lab was founded in the 1950s. You can say the likelihood that a virus would one day escape from one of these labs is pretty high. The likelihood that a given virus would be from a lab is very low. All of which brings us back to where we were at the start. It's plausible and possible but not really likely.
A 2007 outbreak of foot-and-mouth disease (an important virus affecting cattle) was traced to effluent released from a laboratory in the UK [1].
A small number of SARS infections in 2003-2004 are also believed to have been due to laboratory accidents [2].
This article [3] gives an introduction to the subject from the perspective of a journalist who has reported on laboratory safety in the US.
This article [4] published in Nature in January 2012 by members of the US National Science Advisory Board for Biosecurity reviews the risk of a release of an engineered form of H5N1 influenza. It includes some alarming remarks such as:
'We found the potential risk of public harm to be of unusually high magnitude' and;
'A pandemic, or the deliberate release of a transmissible highly pathogenic influenza A/H5N1 virus, would be an unimaginable catastrophe for which the world is currently inadequately prepared'
The authors take the possibility of release of a dangerous pathogen from a laboratory seriously, though the article is prospective rather than retrospective.
For an epidemic to occur, you need not just a lab leak, but a population sufficiently naive to the pathogen. H1N1 was displaced by H2N2 in the late 1950's pandemic, which in turn was displaced by H3N2 in the late 1960s pandemic. Thus it hit the cohort of people aged 25-6 or less who'd never been exposed to H1N1.
That article doesn't support your argument. It just says it was suspected.
I found an NIH article that says the likelier origin is that the 1950 virus was used to produce a weakened live virus vaccine candidate that lead to the reemergence and not an accidental leak. It also concludes by saying there has never been a likely lab leak epidemic ever observed.
That article's definition of "lab accident" seems narrow and legalistic to me. In either case, the virus spent 1950-1977 in a lab freezer. It ended up in the wild, with ~700k people dead. The only question is whether it escaped in an infected researcher (or in infectious lab waste, or in whatever else you'd consider a proper lab accident) vs. in that failed vaccine candidate.
Those details do inform some details of the correct policy response. For example, they determine the relative importance of better PPE at the bench vs. better QA before allowing the vaccine to leave the lab. They don't change the overall question of whether scientific research has ever caused a pandemic, though. That causality is what matters, not whether the sign on the door said "lab" vs. "experimental vaccine nurse".
For example, if the pandemic originated from a WIV researcher who became infected in the field (during their many expeditions to remote bat caves that no other humans would routinely enter), was that a "lab leak"? Literally no, since they weren't in the lab. The causality would still be the same, though--if not for that scientific research, that virus would likely have never left the cave.
To avoid such confusion, it's probably better to say something like "unnatural origin", or "origin arising from scientific research". A much bigger mouthful than "lab leak", though.
I'd add that the article does not state that there have never been cases of accidental releases of pathogens from laboratories, only that such accidents had likely not led to a 'global epidemic' as of the date the article was written (2015).
The article's abstract opens with the statement 'The 1977-1978 influenza epidemic was probably not a natural event'.
These labs are in major cities. Epidemics are likely to be detected in Major cities. The chance of an outbreak being near a research lab aren't as long as you seem to think.
As pointed out in the article, there were exactly 3 cities in the world working on gain-of-function research related to bat-originated coronaviruses. Galveston, Texas, Chapel Hill N.C, and Wuhan. It’s way more narrow than just being near a biological laboratory.
That's not what the person you are responding to said at all. Please stop dishonestly conflating the two theories. You can believe that a coronavirus accidentally leaked from a lab that was studying coronaviruses without believing that it was intentional, or that the disease was a bioweapon.
Honestly, this is not a difficult distinction to understand. You have to wonder why people are so eager to conflate the two.
If it's nothing to do with an engineered virus conspiracy then there's no reason to constrain ourselves to the 1 or 2 labs doing that kind of research. If we don't have that constraint then appearing in Wuhan is much less coincidental.
Listen, if the virus originated in a city that simply had an infectious disease lab, that’s one thing.
For a virus to originate in a city with one of three labs in the entire world conducting heavy-duty researching involving the exact kind of virus that unleashed this pandemic, with the stated intention of working with said viruses to make them more infectious (NOT for the purposes of making a bioweapon) that deserves special consideration. Especially with the fact that the animal the virus is thought to come from ranges 1500 miles south from said city, and started during a time that animal is typically hybernating.
Why? Im not passing judgement on whether it was engineered as a bioweapon. But there was a lab that was actively engaged in research of viruses that are exactly what COVID is. They were conducting research on making said viruses more infectious. I’m not sure why the more likely thing is that it was just a virus sitting in a lab that spilled out, as opposed to a virus that was actively being worked on using the techniques the lab was known to be studying.
You've artificially limited the number of possible labs to those doing bioweapon research. If this isn't your claim there is no reason to do so and if there are more labs studying coronavirus it's far less coincidental.
There is zero evidence that anyone, anywhere in the world was working to develop SARS-like bioweapons. The gain-of-function research in question would have been basic research, intended to develop more dangerous variants of the viruses in order to predict future pandemic emergence, develop more universal vaccines, etc. I believe this research was reckless and should never have been funded (by the USA!) or permitted, even considering only what they knew at the time. It wasn't malicious, though.
In any case, beyond gain-of-function, the WIV and Wuhan CDC also had the biggest program in the world to sample novel SARS-like coronaviruses from nature, from remote bat caves that no other humans had any reason to enter.
If SARS-CoV-2 is a naturally-evolved virus accidentally released by scientists, then Wuhan is the obvious place for it to emerge. That could have been directly from a lab, or a researcher could have become infected on a sampling trip, traveled home from the sampling sites (~900 miles away, to be clear; Wuhan was not an expected natural spillover region), and seeded the infection there. None of this is anywhere close to proven, but the previous dismissal of any unnatural origin as a "conspiracy theory" was an outrageous, unscientific smear.
The lab wasn’t conducting bioweapon research. Gain of function research isn’t to create a bioweapon, nominally. It’s to examine the behavior of viruses under manipulation in order to better understand how we can respond to them given an outbreak. It’s not nefarious by nature, though it does seem like its usefulness hasn’t panned out as was thought.
But again, you really should read the article to understand what gain of function research is instead of insinuating I said COVID was a bioweapon.
They may be, but the WIV wasn't. In the words of Dr. Shi herself:
> We have done bat virus surveillance in Hubei Province for many years, but have not found that bats in Wuhan or even the wider Hubei Province carry any coronaviruses that are closely related to SARS-CoV-2. I don't think the spillover from bats to humans occurred in Wuhan or in Hubei Province.
The closest animal virus to SARS-CoV-2 was found in nature about 900 miles from Wuhan (RaTG13, in Mojiang), closer to Chongqing, Chengdu, Guangzhou, Shenzhen, or HK.
According to Wikipedia the lab had been established many decades ago, "The WIV was founded in 1956 as the Wuhan Microbiology Laboratory" and got its current name in 1978. For better or worse, open, public labs tend to be set up in urban areas, see the insane move of the work done at the Plum Island Animal Disease Center to college town Manhattan, Kansas https://en.wikipedia.org/wiki/Manhattan,_Kansas in the heartland of American agriculture.
Ebola Reston evolved naturally, and emerged in humans due to an infected lab monkey imported from the Philippines to a contract research organization in Reston. Anyone who guessed that it came from Fort Detrick would have been wrong about which lab it came from, but right that it came from a lab.
Put differently, if scientists there hadn't been experimenting with monkeys, Ebola Reston wouldn't have entered humans there. We don't absolve exotic wildlife traffickers or farmers of the consequences of their actions in releasing novel, naturally-evolved viruses; so I'm not sure why we'd absolve scientific researchers.
If there were more evidence that it was lab made then the location would be another point, not to me without further evidence it doesn’t mean all that much.
And there have been 2 emerging coronavirus outbreaks in the last 20 years due to natural origin. Why is it so hard to believe there would be another one.