[kaesar14]

As pointed out in the article, there were exactly 3 cities in the world working on gain-of-function research related to bat-originated coronaviruses. Galveston, Texas, Chapel Hill N.C, and Wuhan. It’s way more narrow than just being near a biological laboratory.

[flukus]

At that point you've subtly moved from lab leak theory to engineered virus theory which is much higher up the conspiracy theory chain.

[tannhauser23]

That's not what the person you are responding to said at all. Please stop dishonestly conflating the two theories. You can believe that a coronavirus accidentally leaked from a lab that was studying coronaviruses without believing that it was intentional, or that the disease was a bioweapon.

Honestly, this is not a difficult distinction to understand. You have to wonder why people are so eager to conflate the two.

[flukus]

If it's nothing to do with an engineered virus conspiracy then there's no reason to constrain ourselves to the 1 or 2 labs doing that kind of research. If we don't have that constraint then appearing in Wuhan is much less coincidental.

[kaesar14]

Listen, if the virus originated in a city that simply had an infectious disease lab, that’s one thing.

For a virus to originate in a city with one of three labs in the entire world conducting heavy-duty researching involving the exact kind of virus that unleashed this pandemic, with the stated intention of working with said viruses to make them more infectious (NOT for the purposes of making a bioweapon) that deserves special consideration. Especially with the fact that the animal the virus is thought to come from ranges 1500 miles south from said city, and started during a time that animal is typically hybernating.

[mikem170]

You do know that there's genetic evidence that seems to point to an origin 600 miles from Wuhan?

> Of 23 samples that came from Wuhan, only three were type A, the rest were type B, a version two mutations from A. But in other parts of China, Forster says, initially A was the predominant strain. For instance, of nine genome samples in Guangdong, some 600 miles south of Wuhan, five were A types. [0]

[0] https://www.usnews.com/news/best-countries/articles/2020-05-...

[lmm]

> with the stated intention of working with said viruses to make them more infectious (NOT for the purposes of making a bioweapon)

Why is this relevant unless you're claiming that the virus that we've observed has been engineered in that way? Otherwise it seems like the chance of a coronavirus outbreak caused by poor handling in a lab is the same for any lab that's studying them for any purpose.

[bananabiscuit]

Good point, now that you mention it, it does now seem possible that SARS-CoV-2 is the result of some sort of engineering tests. Not saying it’s a certainty, but it’s surely at least a plausible consideration.

[dboreham]

I think it may be possible to compute the probability that this is a coincidence. Someone should do that.

[kaesar14]

Why? Im not passing judgement on whether it was engineered as a bioweapon. But there was a lab that was actively engaged in research of viruses that are exactly what COVID is. They were conducting research on making said viruses more infectious. I’m not sure why the more likely thing is that it was just a virus sitting in a lab that spilled out, as opposed to a virus that was actively being worked on using the techniques the lab was known to be studying.

[flukus]

> Why?

You've artificially limited the number of possible labs to those doing bioweapon research. If this isn't your claim there is no reason to do so and if there are more labs studying coronavirus it's far less coincidental.

[tripletao]

There is zero evidence that anyone, anywhere in the world was working to develop SARS-like bioweapons. The gain-of-function research in question would have been basic research, intended to develop more dangerous variants of the viruses in order to predict future pandemic emergence, develop more universal vaccines, etc. I believe this research was reckless and should never have been funded (by the USA!) or permitted, even considering only what they knew at the time. It wasn't malicious, though.

In any case, beyond gain-of-function, the WIV and Wuhan CDC also had the biggest program in the world to sample novel SARS-like coronaviruses from nature, from remote bat caves that no other humans had any reason to enter.

https://www.washingtonpost.com/world/asia_pacific/coronaviru...

If SARS-CoV-2 is a naturally-evolved virus accidentally released by scientists, then Wuhan is the obvious place for it to emerge. That could have been directly from a lab, or a researcher could have become infected on a sampling trip, traveled home from the sampling sites (~900 miles away, to be clear; Wuhan was not an expected natural spillover region), and seeded the infection there. None of this is anywhere close to proven, but the previous dismissal of any unnatural origin as a "conspiracy theory" was an outrageous, unscientific smear.

[wearywanderer]

> There is zero evidence that anyone, anywhere in the world was working to develop SARS-like bioweapons

How do I square that with this claim from the article?

> Eleven of its 23 coauthors worked for the Academy of Military Medical Sciences, the Chinese army’s medical research institute. Using the gene-editing technology known as CRISPR, the researchers had engineered mice with humanized lungs, then studied their susceptibility to SARS-CoV-2. As the NSC officials worked backward from the date of publication to establish a timeline for the study, it became clear that the mice had been engineered sometime in the summer of 2019, before the pandemic even started. The NSC officials were left wondering: Had the Chinese military been running viruses through humanized mouse models, to see which might be infectious to humans?"

What this describes seems like it could be circumstantial evidence of the PLA developing bioweapons. Certainly it isn't proof of anything, and as evidence it's not very strong. But I wouldn't call it 'zero.'

[tripletao]

"Running viruses through humanized mouse models" is a pretty normal (though frightening) part of virology. For example, Ralph Baric was doing it back in 2005:

https://www.pnas.org/content/102/23/8073

So if the Chinese military had in fact been doing this, I'd guess it was just basic research, in the same way that lots of American basic research links back to DARPA. Of course they fund it because they believe there might be a military application, but I see no reason to think that application would be bioweapons (vs. the same kind of beneficial applications described in the open literature).

[peter422]

You don’t think non-scientists have any reason to go into remote bat caves even though bat guano is an incredibly valuable substance?

[tripletao]

Non-scientists obviously go into bat caves all the time, for guano collection, mining, etc. This certainly is a possible pathway for the emergence of zoonotic diseases, including SARS-CoV-2. Those aren't the bat caves I was referring to, though.

The WIV and Wuhan CDC sent grad students to hike through the wilderness to remote bat caves too far from any road or farm to have been exploited yet for any practical use. They chose those caves based on their expert predictions of where they expected to see the greatest diversity of novel coronaviruses.

There's obviously far fewer WIV grad students than guano harvesters; but the risk per person seems orders of magnitude higher, for an expert deliberately seeking a virus vs. a merely indifferent laborer. So that seems like a new and non-negligible risk to me, and thus one that requires investigation. Note that I'm not alone in this; Marc Lipsitch, for example, often mentions this possible pathway.

[kaesar14]

How would guano miners then get to Wuhan and get sick without leaving a trail of infections along the way?

[kaesar14]

The lab wasn’t conducting bioweapon research. Gain of function research isn’t to create a bioweapon, nominally. It’s to examine the behavior of viruses under manipulation in order to better understand how we can respond to them given an outbreak. It’s not nefarious by nature, though it does seem like its usefulness hasn’t panned out as was thought.

But again, you really should read the article to understand what gain of function research is instead of insinuating I said COVID was a bioweapon.