[hamadj]

I think it is a disservice to outright label people as anti-vaxers simply for questioning the risk-calculus of vaccines. The (1/7 million) is the current, unconditional and empirically observed adverse effect of the vaccine - this is a somewhat noisy measure of the true prevalence of this issue. It is okay to be cautious and there are legitimate concerns, and quite frankly, I trust the FDA have good reason to pause this if Moderna/Pfizer are readily available anywy. In countries where there are not alternative vaccines available, the risk calculations change, and as such, you might be better off taking J&J or AZ. In any case, to your earlier point of why they stopped it: they didn't stop it because (7/7 million), they stopped it because it was not observed in the trials and now they have to recalculate the risks for various age-groups and inform people, accordingly. If these events were observed in the trials and the prevalence was the same (in trial, and out of trial) then it would not be a cause for concern.

Edit: got the wrong agency, it was FDA, not CDC

[arcticbull]

> The (1/7 million) is the current, unconditional and empirically observed adverse effect of the vaccine - this is a somewhat noisy measure of the true prevalence of this issue. It is okay to be cautious and there are legitimate concerns, and quite frankly, I trust the FDA have good reason to pause this if Moderna/Pfizer are readily available anywy.

How many injections do you personally need to feel comfortable? Seven million people is way more than any clinical trial for any drug you've ever taken, and I guarantee you any of them is more likely to kill you.

Every single year 150 people die from taking Tylenol in the US in the normal course of treatment -- and 500 die of acute liver failure due to acetaminophen overdose. 25,000 hospital admissions. 50,000 ER visits. If we pretend that 350,000,000 people take Tylenol each year, that makes Tylenol 50% more likely to kill you than this vaccine.

It's simply not ok. They are anti-vaxxers.

[vmladenov]

This comment is a prime example of why we’re in this mess with vaccine denial in the first place. You’re either not allowed to say anything negative about vaccines, or you’re an anti-vaxxer who thinks your kids will get autism and 5G chips. It’s so cult-like.

We should be honest about the (low) risks and benefits of vaccination without turning it into a political campaign of shame and bullying, and trust people to make the right choice for them and the public.

Perhaps you also think the US government is anti-vaxxer, as it runs a publicly funded National Vaccine Injury Compensation Program - https://hrsa.gov/vaccine-compensation/index.html

[refurb]

Exactly this. A lot of conversation seems to ignore how humans behave. Pausing, examining data and restarting with updated guidelines further encourages confidence in the process.

Imagine if the FDA says "no big deal, low chance of it happening, keep going", then a week from now "oh seem like the rate has doubled, still low, keep going", then a week later "ok, if you have any risk of blood clots don't take the J&J vaccine". That scream "we didn't think this would happen".

You've just eroded trust in the system and the next time some weird side effects comes up you won't have to pause, people will just refuse to take it.

[arcticbull]

IMO, no - I'm saying that folks risk management is completely out of wack. The chance the disease kills you is 1 in 100. The chance that the vaccine kills you is 1 in 7 000 000. One is bigger than the other. By, like, a lot.

The government's response is to pacify anti-vaxxers.

[vmladenov]

Again with the made up numbers that erode trust.

I’m 25 and I’m relatively healthy. The risk that the disease kills me is significantly less than 1 in 100; it’s hard to find numbers but one chart had the hospitalization rate for me at 1%, and the death rate 0.01% (edit: though the death rate only covered age and didn’t divide by other factors such as obesity). The “chance” the vaccine kills you is currently zero as there have been no recorded deaths that have been linked to a COVID vaccine. The blood clotting risk has been cited as 1 in a million, but we’re working with limited data. This is the problem with making such extrapolations.

I write all of this as I’m on day 2 of dealing with the side effects of J&J.

[arcticbull]

Yep, I used averages not made-up numbers.

The reason everyone has to get it is so that the average goes down to 0, for everyone.

7 million trials is not limited data. It's dramatically, and I do mean dramatically more data than basically any other clinical trial for any other drug you've ever heard of. By probably 2 orders of magnitude. It's simply not limited data.

The average phase 3 trial has 300-3000 participants [1]. Not seven million.

Also a week in after J&J.

[1] https://en.wikipedia.org/wiki/Phases_of_clinical_research

[ryankemper]

> The chance the disease kills you is 1 in 100

It's 6 in 1000 if you listen to the CDC; personally I think the real number is closer to 3 in 1000. That's not too far off from what you said but I prefer being more explicit rather than using such a fuzzy resolution.

And just to be explicit, that's the general IFR, the IFR for, say, people in their 20's, or even people in their 40's, is a fraction of that.

---

Anyway, your point about risk management is somewhat true, but it is much more true if you apply that logic to the general public's fear of SARS-2 in the first place. I can't find it in my notes but surveys that have asked people what their chance of dying is if they catch the virus, are off by MULTIPLE orders of magnitude. And young people rank their individual risk of death higher than old people do (both estimate too high, even the old people), presumably due to them being more "plugged in" to "the system" so to speak.

Personally speaking, since I'm in my 20's, almost everyone I know who has gotten the vaccine has done so because they believe outright falsehoods about the virus that have been propagated not just by the media but by our so-called health experts themselves.

For example, I have multiple friends who had PCR-confirmed COVID-19, recovered months ago, and still got the vaccine. In the times I've probed at them to see why, they muttered some vague things about "the variants" and essentially said that the variants bypass naturalistic immunity which is just completely false.

I know for a fact that my likelihood of an acute adverse reaction (the all-too-common "feeling like death for a day" reaction) is far higher than the likelihood of comparable symptoms from SARS-2 infection. So I'm not getting the vaccine, and I'm not embarrassed to say so. For many people, the risks of the virus are less than risks of the vaccine; however, much less people than you would think. We don't have good enough data yet but I'd bet it crosses over somewhere in the 40's or 50's age range.

There's a huge difference between being an "anti-vaxxer" in the true sense of the word - i.e. you think all vaccines are inherently bad, period - and being someone who takes the same attitude towards vaccines that we do towards drugs: no drug is inherently safe; rather drugs that are proven to be safe are safe. By extension, no vaccine is inherently safe; vaccines that are proven to be safe are safe.

The latter statement is my personal view of it, and unfortunately such a statement can get you banned from social media platforms if you get unlucky.

This binary way of dividing the world into "anti-vaxxer" vs not, "AIDS denialist" vs not, etc is not just oversimplified but is intentionally done to suppress dissent. I refuse to participate in such a culture and I humbly implore you to do so as well.

[hamadj]

> How many injections do you personally need to feel comfortable? Seven million people is way more than any clinical trial for any drug you've ever taken, and I guarantee you any of them is more likely to kill you.

Again, the point is, when we observe adverse effect in the out-of-trial phase, it has hard to pin-point cause and effect. It is not a guarantee that the 7 million necessarily represent a random sample so proceeding with caution is warranted. We know, for example, vaccines have been distributed by age, and chances are, the 7 million is bias towards the older demographic.

> Every single year 150 people die from taking Tylenol in the US in the normal course of treatment -- and 500 die of acute liver failure due to acetaminophen overdose. 25,000 hospital admissions. 50,000 ER visits. If we pretend that 350,000,000 people take Tylenol each year, that makes Tylenol 50% more likely to kill you than this vaccine.

Again, the point isn't that {insert_your_favourite_drug} is 10x more likely to kill you - the point is, when we do not understand why something is happening, it is better to pause and detect whether there is a more fundamental issue. For example, suppose that every single injection that caused an adverse reaction was produced at the same facility and as part of the same batch - we would definitely be better off in investigating the root cause than to leave it be. Until we fully understand what mechanism is causing this adverse effect and how to best counteract it, in my opinion, a pause is warranted.

[arcticbull]

Sure, in isolation, that's all true. However, in isolation, the cost of doing nothing is zero. In a pandemic where 70% of America will catch a disease somewhere between 0.3% and 1% fatal, the cost of doing nothing is dramatically higher than zero. In fact, it's dramatically higher than a vaccine that just randomly kills 1 in 1,000,000 people - which this one strictly does not.

My point is that yes, an investigation should be carried out, but stopping the trial obviously - trivially - does more harm than good due to the extenuating circumstances of the global pandemic.

[heywherelogingo]

Agreed, I've had all other vaccines, but this batch is rushed, experimental, and not necessary for me - labelling people such as myself "anti-vaxers" is just dishonest, bitter, childish, name calling. Very few people in my area of London have bothered with the so-called lockdown (too much was open to be called a lockdown), masks, etc - I expect I've had all variants, and apparently my immune system is on top of it, in which case there's nothing to pass on; and the people in my area clearly don't care if I did. I'm no more an "anti-vaxer" than I am an anti-martian.

[jrockway]

Did you get an antibody test to confirm that you've already had it? I don't think data supports the assumption that you've already had it; it's a rare disease even where it's spreading widely. I also have a gut feeling that people didn't take "lockdown" or social distancing seriously, but some counterevidence is that nobody in the UK has gotten the flu in 2021: https://www.independent.co.uk/news/health/flu-cases-covid-en... That's not because they're already immune, it's because diseases simply aren't being transmitted. As bad as people are about masks and social distancing, there is some measurable effect.

I'll also point out some anecdata. I know someone in their late 20s that got COVID. They have felt miserable every day in the 9 months since having it. Others have relayed similar stories. Public health authorities are worried about severe consequences like death, but death isn't the only possible outcome. You could just feel like shit for the rest of your life.

To me, this is a nasty disease that I do not want to contract. I probably won't die if I get it, but there is more to life than merely not being dead. As a result, I got the vaccine as soon as I could.

[atleta]

Well, you may not be (or see yourself) an anti-vaxxer, and your right that it's not necessarily wise to label everyone as such who have concerns with these vaccines, but it also doesn't mean that your excuses make sense.

The batch is not "rushed" more than it's needed: there IS an emergency. It's also not experimental. The experiments have all been done (up to phase 3). It's perfectly normal to only see 1 in a million (or even 1:100 000) side effects after starting the vaccination of the general public. Simply because the phase 3 will never contain millions of people. I've checked, and the 30-40k studies we had with these seem to be indeed large. I.e. safe.

What you think about your immune system is kind of irrelevant for a few reasons, but talking up their immune system seems to be a general self-convincing strategy for a lot of people. First of all, it's not apparent that you have contracted the virus. Unless you have an antibody test showing that you are seropositive, you simply don't know, but the chances aren't very high. What you can be sure about is that you have not contracted "all" variants. If you live in the UK then you had the chance to meet the UK variant (B117, IIRC) and the base variant (D6.... whatever). Very likely not both. And the immunity for the base variant seems to work pretty well for the UK variant, so it doesn't even matter if you met both.

But even if you know you are already immune, the natural immunity doesn't last that long. The vaccines give you higher antibody levels (at least the mRNA ones do, again IIRC) and better immunity especially due to the second dose. (Which you can't really simulate with a second infection within a few weeks.)

And at last: you can't generalize from your own experience. Looking at the numbers, which we do have a lot of, people who haven't met the virus and don't have immunity should by all means get the vaccine. Because the virus is a lot more dangerous (several orders of magnitude more dangerous) than even the J&J or the AZ vaccine. Though the exact risk profile will depend on individual factors, of course, but since you've talked about all vaccines...

[argvargc]

Zero experiments have been done on long-term effects, and you cannot, and no one can, counter this point.

That's the definition of "rushed".

Vaccines typically take several years of testing before being approved. These aren't approved according to those standards. Manufacturers are absolved from risks because of this "emergency use" status. Why absolve them if there are no risks? If they truly believed these were safe and of tremendously important benefit, they could stand up and say "we accept responsibility for negative outcomes in accordance with ordinarily approved medication, and waive our rights to emergency use protections". Then everyone would rush to take them as doubts would be broadly eliminated.

[jrockway]

Things are "rushed" because it's an emergency. SARS-CoV-2 has existed for a little more than a year, and it's already killed 3 million people. At some point, you have to take the leap of faith that this thing that's very much like other things is going to actually be very much like those other things. mRNA vaccines are not new. Adenovirus vaccines are not new. Vaccines are brought to market in less than a year routinely; consider the seasonal flu vaccine.

(Why are we seeing mRNA vaccines for COVID and not other diseases, if it's not new technology? Because the vaccines for other diseases didn't work.)

You are totally right that there could be some magical protein in the vaccines that causes you to drop dead in two years. There probably isn't though, so what you call "rushed" other people call "saving lives".

[argvargc]

9 million - including many children, and mostly people of colour - die each year of starvation. Where's the emergency, trillions and unprecedented worldwide cooperation and effort to eradicate that forever within less than a year? It doesn't even require the invention of anything new, and is primarily a logistical (/expense) problem. Would save three times as many lives just in the first year, overwhemingly more life years overall, and be much easier to implement, being confined to mainly a few known, poorly-resourced areas (rather than the entire earth).

If you've seen or lived the effects of starvation firsthand, you'd find it difficult to understand why suddenly everyone is willing to do anything, even destroy their own livelihoods or take rush-developed intravenous shots, to try and save the lives of a significantly smaller number of predominantly elderly people who were about to die of just about anything else anyway, at the expense of those 9 million (or any other of preventable causes of death that kill in higher numbers per year and have been known about for decades, for example: smoking).

Why not spend a year making the manufacturing of cigarettes illegal, have a worldwide crackdown with cigarette company executives hauled to jail for crimes against humanity, make it illegal to depict smoking in any media, censor all images of cigarettes, and launch a 24/7 every news channel, every street corner propaganda campaign, with celebrities publicly blacklisting smokers?

Save significantly more lives in the first year, and keep doing so year after year. Wouldn't need to trash the economy, ruin businesses, or risk plunging anyone into poverty, etc - and no need for anyone to take a rushed, long-term untested shot.

[atleta]

> 9 million - including many children, and mostly people of colour - die each year of starvation.

The sad thing about this kind of argument is that it never goes away. Whatever happens. I started an argument more than a year ago with a guy, when we had 3000 deaths. World wide, total. He kept saying that it's less than the number of people who die in car accidents in a day. And he was right. What he didn't get is that without counter-measures it would grow exponentially for quite a long time and to quite a large total.

And it did grow and we continued this argument for months (with 1-2 comments a month) he had to keep raising the stakes. Next it was less than the number of flu deaths per year, next it was less than the number of car accident deaths, this time per year, then the number of HIV deaths, and then he just stopped arguing. I pinged him at 1M last June, never responded. I don't think he changed his mind.

I see your argument as a continuation of that. You just raised the stakes again, but however much the total count will be, you guys will always find something bigger. Implicitly stating that it's only worth taking counter measures against the worst cause of death. (Be it lockdowns or vaccines.) But it doesn't make sense. This is ON TOP of all those. Also, let's not forget that the only way we managed to keep it down to 3M is by imposing pretty strict lockdowns worldwide. Without those it would have been a lot worse. And even with these lockdowns the health care system is waaay overloaded in a lot of places, which means that COVID kills indirectly as well.

Yes, help people who are starving: we can easily do so by donating money. As long as you have the money. But don't make it worse by not vaccinating and letting COVID kill others, kill even those who are very poor (they definitely have worse chances) and kill the economy which obviously means more people starving and less help for those who have already been starving.

[atleta]

You're mostly repeating the claims of GP and I have already responded to these. Esp. this one: "Vaccines typically take several years of testing before being approved."

The so called long-term effects have been mostly non-existent with any vaccine. First of all, the very expression "long-term effects" is vague. Do we mean effects that only materialize over the long term (i.e. a long time after being administered) or effects that last for a long time? The latter can be known (well, with a worst case estimation) even with short testing.

And as far as I am aware, there is very little evidence of the former happening with former vaccines. I.e. the vaccine inducing some systemic change in your body that remains undetectable for years.

> If they truly believed these were safe and of tremendously important benefit, they could stand > up and say "we accept responsibility for negative outcomes in accordance with > ordinarily approved medication, and waive our rights to emergency use protections".

First of all who? You seem to mingle several groups into one here. It's not the pharma companies who believe that that these are very important, but the society. (Well, at least the ones who don't live in denial.) The importance stems from the seriousness of the epidemic.

And safety is not a binary/boolean attribute. Safety can be measured and the accuracy of the measurement has a confidence (i.e. a probability that it's within the estimated limits). Now the claim is that this measured safety is way above the safety of contracting COVID. And this is the very reason we know that it's beneficial. For the society. It's pretty clear that pharma companies don't make nearly as much profit as much it is beneficial for the individual countries. Just try to add up the cost of the lockdowns e.g. for a year and then devide it by the number of doses and see how much they should cost if calculated like that. You know what, let me do the math for you: a year of lockdown has been estimated to cost 251bn GBP for the UK[1]. The UK has 66M population. Let's calculate with 266M doses. That would give you 19GBP/dose (~26USD) for the vaccines per dose. Per year. But they won't vaccinate everyone, 80% would already be an over estimation (which would increase the value of price/dose to 32.5GBP and we're not just talking about money we're also talking about lost lives and a lot of frustration, which would further increase the value of these shots.

Comprared to that, the AstraZeneca costs about 2USD, IIRC, the EU pays about 16EUR (14GBP) for the Pfizer/Biontech one.

So it's not that the tremendous value gets all snatched up by the pharma companies. Also, they do have a responsibility. In the US they have been waived, but not in the EU. And guess what: a lot of people keeps saying the same things over here. (Including* that they don't take responsibility.)

The reason the US waived these companies is exactly because the vaccines are so important and valuable for the sate (i.e. for the people). A quick rollout was more important for them, than for the pharma companies. As a side note: some politicians over here (EU) think that the US did it the right way by not wasting time on negotiating hard with the pharma companies and that the EU is behind exactly because of that and that we should have waived them as well. (I'm not sure I buy into it.) But the EU non-waiver is an assurance for everyone else, including the US citizens. Yes, you may not get a million $ check if you happen to be unlucky, but it still shows that the companies indeed do have the confidence in their product you were talking about.

[1] https://www.theguardian.com/business/2021/mar/22/a-year-of-c...

[thelean12]

You may not be full on anti-vax, but you're very clearly anti-science.

> I expect I've had all variants

No evidence of this.

> and apparently my immune system is on top of it

No evidence of this.

> in which case there's nothing to pass on

Even if the above were true, we don't know how long you'd have immunity.

> and the people in my area clearly don't care if I did.

They would if they caught it and had severe symptoms.

[tryonenow]

Resorting to calling people "anti-science" is just as counterproductive and unnecessary as calling them "anti-vax". You're only solidifying animosity and mistrust. People have every right to question what they're being told by the same governments who mishandled this epidemic from the start - especially since there such strong political incentives that aren't necessarily aligned with scientifically based recommendations.

[jimbokun]

You are vaguely waving your hand at unspecified "political incentives" with absolutely no specifics or evidence of anything.

I mean, you can question anything, but that has about zero value. Answers with evidence backing them have value.

[ironmagma]

Everything should start from a place of questioning. If there is data and the data makes sense, that can replace questioning with certainty. But often the data has a limited or tenuous connection, possibly even a fraudulent connection. This is why it’s important to actually read the studies and understand the science, not just to hand wave it away as “evidence = value.”

[tharne]

The technology behind this vaccine has been actively worked on for over a decade. Yes, these vaccines have been sent to market faster than normal, but they certainly have not been "rushed".

[ryankemper]

I hear this line being trotted out all over - especially from the "experts" - and I find it nothing short of enraging. There is a difference between saying "an mRNA platform in general might not be safe" and the actual claim real people make which is "this specific vaccine has not existed for more than a year and is being hastily rolled out on the world population via implicit or explicit coercion". The mRNA platform in general can be safe and, say, the Moderna vax could still have a poor safety profile. This is why we perform rigorous long-term testing and why most vaccine approvals (not that these are FDA approved of course) take several years.

If you can't be intellectually honest enough to admit that there is a difference between "we've used this platform in theoretical research in small numbers" to "we mass-market and roll out this novel vaccine to billions of humans worldwide", you shouldn't be in the discussion, IMO.

[8note]

It's the same thing with flu vaccines, mind you. They only get a few months testing before entering mass use

The speed of access for these vaccines is that they started mass production while testing was ongoing, rather than waiting until after testing to start production

[meepmorp]

It's not an mRNA vaccine; it uses an adenovirus vector, like the Oxford/AZ virus.

The mRNA vaccines both seem to be fine, by comparison.

[ryankemper]

Thanks for the important clarification; I didn't read closely enough.

My argument was definitely tailored for the mRNA discussion, although the purpose was more to illustrate the broader principle, but, not knowing a whole lot about adenovirus vector vaccines specifically, is it even the case that adenovirus-vector vaccines have been widely used in the general population?

I couldn't find great info with a cursory search (indeed the top result is the CDC which consistently fails to cite anything they ever claim, ugh), but I wonder if the general argument still applies for these types of vaccines as well.

Anyway, thanks so much for catching and pointing out my error there.

[meepmorp]

I believe there's an Ebola viral vector vaccine. The only other ones approved for use are for COVID, so it is definitely a newer technology.

fwiw, new and better better technologies need to get used for the first time, eventually.

[clcaev]

J&J is not mRNA platform, it uses an adenovirus platform.

[ryankemper]

Thanks. To avoid repeating myself: https://news.ycombinator.com/item?id=26799734

TL;DR you can probably s/mRNA/adenovirus vector/g although I will grant that adenovirus vector seems less "experimental" than mRNA does

[atleta]

It's not dishonest. It's a very adequate answer to the over-simplifying claim above. I.e. there is a difference between a newer and an older platform and there is a difference between an experimental platform and a new platform (that's not experimental but has been in development for a long time).

You can always argue for making things slower and experiments longer, the problem is, that there is a pandemic going on with 3M deaths in the past year. Actually people seem to think that you can develop vaccines without being rushed, but it doesn't seem to be the case. There are several reasons why other vaccines took years:

- it was a long time ago and scientists had a lot less knowledge, experience and older technology. (Think e.g. the mRNA vaccines, which J&J is not one of, where the first candidate could be completed in something like 2 weeks after the isolation and sequencing of the virus.) - they had to start from 0 for a new virus (because they new less, etc.). Like for the polio, or HIV. In the case of SARS-CoV2, they could build a lot on the experiments from SARS-CoV1. As far as I know, there was a vaccine candidate back in 2003, but by the time it would go into phase-3, the epidemic was over. Also, it seems that research never stopped about the coronavirus vaccines, so there were new results between 2003 and 2020 that the mRNA vaccines built on. - some viruses are easier to develop a vaccine for. (E.g. the HIV is not one of them, because it's very good at evading the immune system) - I've already mentioned this, but if the vaccine candidate doesn't get ready on time because of the above reasons, then you may have to wait for years before you can do a phase3 trial because there will be no people getting infected, so you won't be able to measure the effectiveness. This is what happened with the ebola vaccine in 2014. Now the vaccine is 7 years old, but it doesn't make it any safer, because there weren't people who could be vaccinated. (Well, of course, you could vaccinate them and wait for any long term side effect, just in case, that would show up without being infected, but that doesn't seem like a very important data point.)

But again: why would you want to wait for several years in a situation like this when we do have a pretty clear picture of both the worst case risks of the vaccines and the risks of the disease (which are higher than the worst case risks of the vaccines).

[ryankemper]

> It's not dishonest. It's a very adequate answer to the over-simplifying claim above.

I would disagree that calling it "rushed, experimental, and not necessary for [the original commenter]" is an over-simplifying claim. Indeed I find the "we've done theoretical research with platform X for years" to be the oversimplification. That being said I do agree that there is a difference between an experimental platform and a new platform.

> But again: why would you want to wait for several years in a situation like this when we do have a pretty clear picture of both the worst case risks of the vaccines and the risks of the disease (which are higher than the worst case risks of the vaccines).

Starting with the "higher than the worst case risks of the vaccines" part, FWIW, this is true in general but not for all individuals. For someone like me (20's, active, no major health conditions), the acute side effects of getting a SARS-2 vaccine far outpace the expected level of symptoms from SARS-2 infection itself. (Speaking from a personal risk reduction standpoint only, I don't want to get into the ethics of medical collectivism for the purposes of this discussion). I don't think you would dispute that, but just wanted to mention it because it's because taboo (and indeed you can get actively censored) to say "for my specific health circumstance the vaccine is more dangerous to me".

As for the more general point about understanding the risks of the vaccines and the disease fairly clearly, I would say that we understand the virus far better than the vaccines. Indeed it really saddens me how we've wasted public health dollars on messaging to people that immunity to reinfection is not a thing (when it is most definitely a thing) and to be super spooked about variants despite the fact that SARS-2 is not going to magically mutate away from the spike protein anytime soon (i.e. there's plenty of epitopes for our immune system to work with even for the highly artificial immunity produced by making the body's cells manufacture spike protein exclusively).

I will grant though that we have bounds on how bad short or medium-term adverse reactions could be to the vaccines. Personally I worry less about the (using mRNA as an example here to illustrate a general point) "it's going to turn me into a human GMO" pseudo-argument than I do things like (a) "is the rate at which spike proteins get produced in the body much more of a steep increase followed by a steep dropoff leading to greater potential for acute inflammatory episodes than via naturalistic infection" as well as (b) "could we be over-sentitizing the immune system to react too strongly when it detects spike protein, particularly for those who already had COVID-19 before ever getting the vaccine". If you're not aware, an absurd amount of people who have already gotten COVID-19 and therefore have naturalistic immunity are still getting the vaccine, either because they're "required" to (aka they don't know or want to fight their job's requirements) or more often because they've been brainwashed to think that the variants evade natural immunity which is just a total media-propagated falsehood.

> In the case of SARS-CoV2, they could build a lot on the experiments from SARS-CoV1

Totally agreed and I wish more people knew that the virus causes COVID-19 is called SARS-2 and that it is directly related to SARS-1 (I'm referring to layfolk here). As a separate tangent I wish more people understood that the emergence of SARS-2 means we don't really need to worry about SARS-1 anymore because anyone exposed to SARS-2 will be cross-reactive with SARS-1.

> I've already mentioned this, but if the vaccine candidate doesn't get ready on time because of the above reasons, then you may have to wait for years before you can do a phase3 trial because there will be no people getting infected, so you won't be able to measure the effectiveness.

This is simply not the case for an endemic seasonal respiratory virus. You'll have plenty of cases, especially since we're basically PCR-testing the whole globe (I don't think we should be, to be clear). But I totally agree that the apparent benefit of vaccines declines exponentially as time goes on, particularly with SARS-2 where the fact that it is deadly for the very elderly and harmless for the very young means that yearly recurring mortality is going to essentially vanish after it's propagated through the current world population (as an aside, this fact is one of many reasons why all the hysteria around the virus was absurd from the get-go; amortized over several years the mortality of SARS-2 is entirely unremarkable)

> But again: why would you want to wait for several years in a situation like this when we do have a pretty clear picture of both the worst case risks of the vaccines and the risks of the disease (which are higher than the worst case risks of the vaccines).

Yeah, to conclude I want to bring it back to my earlier point which is that once the virus has propagated through the current world population (more or less), the set of SARS-2-naive individuals will become dominated by the very young, who are not at real risk of COVID-19 and therefore they will develop immunological memory while young when they are incapable of being harmed by SARS-2. This means that recurring yearly mortality will fall off a cliff (albeit, if we keep labelling deaths the way we do we won't see that reflected in the numbers nearly as much as we should). Which is why I think the restrictions and everything else, even if they had worked in places like the US or Europe where they totally failed, were always a bad idea. But the other side of that coin is: yes, insofar as you do think SARS-2 is something worth really freaking out over, we absolutely have to rush the vaccines because if we wait 2 years then there won't be any real COVID-19 deaths left to mitigate.

[pyronik19]

They slapped the word "experimental" on the disclosure form and waived liability to the manufacturer... it was rushed... as it should be. I took it. But the reason people don't "trust the science" is that its obvious people are lied to on a regular basis around covid and trust has flatlined.

[arcticbull]

> Agreed, I've had all other vaccines, but this batch is rushed, experimental, and not necessary for me - labelling people such as myself "anti-vaxers" is just dishonest, bitter, childish, name calling.

No, it's not. That's a misunderstanding of how the vaccine development process works and what takes time.

What takes time in the normal course of development is testing the vaccine, yes. Specifically, determining how effective it is. The reason that takes so long is that in general there are very, very few cases of most of the diseases vaccines are developed to prevent -- and you can't just go giving people Ebola to check how many of them catch it.

It's fearmongering, plain and simple.

There's mountains of data for your perusal online explaining how and why it got done fast -- here's one example. [1]

[1] https://www.immunology.org/coronavirus/connect-coronavirus-p...

[koolba]

Nine women cannot work together to produce a baby in one month.

Similarly, while wider population testing for safety and efficacy would likely correlate with long term safety, it’s not a total substitute.

I think it could be completely rational for young, healthy, low BMI people to delay vaccination till they’re more comfortable with any potential long term issues.

[arcticbull]

Well I guess it's a good thing nobody's trying to produce a baby, but rather, a vaccine. Because they succeeded, and you hand-waved away my completely rational explanation with a nonsequitur about pregnancy.

Those folks aren't being immunized to protect themselves but those around them. This is a team effort and everyone's gotta pitch in.

I got my J&J a week ago. No side-effects here.

[loveistheanswer]

If you've already had the virus, and had only mild symptoms from it, what additional level of protection does the vaccine confer?

Do you still really need to get the vaccine in that case?

The CDC says yes, but their reasoning is purely based on FUD: "experts do not yet know how long you are protected from getting sick again".

According to the available data, there has been only 71 confirmed cases of reinfection out of over 137,000,000 cases.[1]

Meanwhile, states in the US are reporting hundreds of "breakthrough cases" of fully vaccinated people.

So, the data we have indicates naturally gained immunity is stronger than vaccinated immunity.

It's funny how many people treat nuanced, data driven discussion like this as heresy to be shamed and censored.

[1]https://bnonews.com/index.php/2020/08/covid-19-reinfection-t...

[thelean12]

> I think it is a disservice to outright label people as anti-vaxers simply for questioning the risk-calculus of vaccines.

It's the same idea though, and should still be called out. It's people who have unqualified medical opinions, and who are then often spreading that opinion to others as if it's useful.

Let the agencies figure it out, pay attention to the latest recommendations from them, and go with that. Anything else is just the blind leading the blind and should be called out.

[ironmagma]

Careful to not play the appeal to authority. Anyone can understand anything, regardless of their so-called qualifications. Are they likely to? No, and that’s why someone’s qualifications are purely a heuristic, not a prerequisite.

[ryankemper]

It's extra frustrating because organizations like the CDC get held to lower standards than anyone else. They can make a pronouncement recommending the use of face masks for SARS-CoV-2 community transmission when the body of the research confirms that (a) such intervention has never been tried in an RCT and indeed the whole "my mask protects you" hypothesis is intentionally unfalsifiable, (b) the research literature documents numerous negative impacts whereas the positive impact on transmission is completely unproven at best, and yet their evidence-less pronouncement is considered evidence in its own right and such a pronouncement is used as a citation in Wikipedia articles, etc.

(Just using masking as an example, if any onlookers strongly believe that masking is efficacious for the stated purpose just imagine I gave a different example, although I don't see how anyone could reach that conclusion about masking specifically based on the research literature out there which is neutral at best)

Or as another example, the CDC loves to try to encourage people to take the flu vaccine, and yet I was shocked to discover that it takes 71 flu shots to prevent a single flu case, 29 flu shots to prevent one ILI (this is a better number than the flu case number since really we care about ILI in general, but even so 29 is an abysmal number), AND that regardless of the mediocre reduction in cases/ILI, it makes essentially no difference in hospitalizations.

Citation on the flu vaccine stuff: https://www.cochrane.org/CD001269/ARI_vaccines-prevent-influ...

--

I didn't realize until this year how much of "public health" involves (a) actively and intentionally lying to the public (for example, if you read about the AIDS crisis you learn about the "noble lies" told about who was vulnerable as well as the not-even-noble lies like when Fauci told people you could get AIDS from close contact with someone with AIDS when the scientific evidence showed that to be false), and (b) is really a giant marketing campaign for various big pharma interests (I say that as someone who is an unashamed free-market capitalist, not that the US is actually a true free market when it comes to the pharma/medical industry)

[thelean12]

I'm not insisting that a claim is true just because an authority says it is. You can't just bring up "appeal to authority" and call it a day.

I'm insisting that the average unqualified individual should not think they have a better chance of being correct over the authorities in question.

There's no other rational option for unqualified individuals than to listen to medical authorities unless you have a medical degree yourself and have read and analyzed the research yourself.

[ironmagma]

There are actually a lot of reasons to be skeptical of experts — the same as why you should be skeptical of anyone. Appeal to authority has a contrapositive: the disappeal to lack of authority. The arbitrary person can be right just as much as the expert can. The whole point of logic and reason is that it’s about facts, not the people.

Critically the problem with your reasoning is the last sentence. No, you do not need to have a medical degree to be right when a doctor is wrong; ask anyone who’s had a medical issue that all doctors agree does not exist.

[vmladenov]

Isn’t that inverse, not contrapositive? Here’s how I’m understanding it:

> appeal to authority

authority -> trust

> disappeal to lack of authority

not authority -> not trust

The contrapositive of the first proposition would be

not trust -> not authority

which is a rather different claim.

[ironmagma]

True, the word was wrong. The point though is that for this logical fallacy, there is an equal and opposite logical fallacy. Saying authority implies truth is just as wrong as saying lack of authority implies falsehood.

[rajin444]

How does authorities being wrong / changing their recommendations factor in to what your consider a rational option? If you were a high risk individual back in January 2020 who ignored their advice and quarantined + wore a mask (an effective mask, i.e N-95), you made the right choice.

Despite how much smarter and informed humanity is, we still make decisions based on trust. Science can only explain so much and runs out of answers eventually.

[thelean12]

> If you were a high risk individual back in January 2020 who ignored their advice and quarantined + wore a mask (an effective mask, i.e N-95), you made the right choice.

Did they? Or was the chance they'd come in contact with Covid at that point very low and those masks would be of much better use at hospitals where the chance of coming into contact with Covid was very high? At least, that was what the experts were saying at the time. I donated my N-95 masks (that I had from California fires) not because we thought they didn't do anything in January 2020, but because the experts said they were of better use in hospitals.

> Science can only explain so much and runs out of answers eventually.

You say this as if there's a better place to find answers. Where is that place?

[rajin444]

> Did they? Or was the chance they'd come in contact with Covid at that point very low and those masks would be of much better use at hospitals where the chance of coming into contact with Covid was very high? At least, that was what the experts were saying at the time. I donated my N-95 masks (that I had from California fires) not because we thought they didn't do anything in January 2020, but because the experts said they were of better use in hospitals.

You're saying a high risk person (high risk meaning they would likely die from covid - immunosuppressed, etc.) wearing an N95 mask and quarantining was a bad choice? I'm not sure how those masks would be better used if the person is at a high risk of dying to covid.

> You say this as if there's a better place to find answers. Where is that place?

Interpreting all the data available to you. Would you have shamed a person for not choosing this man as their surgeon https://en.wikipedia.org/wiki/Christopher_Duntsch after they researched his past operations. There are more factors than just the research that need to be considered.

[AndrewBissell]

In 2012 if someone decided against their doctor's advice not to take an opioid which the FDA had greenlit as safe in far too many cases, would you call that "blind leading the blind"?

Iatrogenesis rivals strokes as a cause of death. Most doctors are just slavishly following official doctrines from authorities, and sometimes those authorities get it wrong. We don't even have to look to the Before Covid Times to see examples!

[thelean12]

> sometimes those authorities get it wrong

Yes. That's correct. That doesn't change what I said.

Answer me this: why do you think unqualified individuals are better suited to get it right?

Just because there are examples in the past of people who went against the recommendations who ended up being right, doesn't mean you should take everything else into your own hands. Unless, of course, it's literally your job.

[blitz_skull]

It’s not a question of getting it right, really. I haven’t heard a single uneducated opinion say, “You should not get it because X”. I’ve seen several say, “I will not get it because X”

It’s a subtle, but IMO important distinction. If people wanna rationalize not getting the shot based on their own misunderstanding of the science, that’s fine. That’s okay.

We don’t need universal understanding here for the vaccine to do it’s thing. Let those who want to get it, get it. And those who don’t, to not get it.

[thelean12]

> I haven’t heard a single uneducated opinion say, “You should not get it because X”.

It's not even 3 hours into my day and I've already received 3 texts from family saying something along those lines regarding J&J, even if it gets unpaused. It's a much more prevalent thing to say than you think.

> If people wanna rationalize not getting the shot based on their own misunderstanding of the science, that’s fine. That’s okay.

It's not okay. We need shots in arms. And you're doing your part by enabling those who are misunderstanding the science by making them feel like it's okay to not get the shot.

[spion]

That's a good method to not develop immunity and develop resistant strains.

[cbkeller]

Deciding that your pain is well managed without opiates has always been a perfectly reasonable and medically-accepted option, and unsurprisingly there has never been any sort of social stigma against people who decline painkillers.

Most to the point, declining to take painkillers does not adversely impact other people's health.

This is not a good analogy.

eta: ironically, the problem with the opioid crisis was not too much regulation and oversight by "the authorities", but too little; too much freedom for doctors to prescribe stronger painkillers, and for patients to request them.

[JoshuaDavid]

I agree that, unless you have specific concrete reasons to think a public health agency is distorting the facts or making decisions based on politics and ass-covering instead of optimizing for health, you should trust that agency. However, once you have concrete reasons to think that the public health agency is acting on politics and not science, you should not continue to blindly trust them.

There are other sources of information besides the public health agency of your particular country, for example public health agencies in other countries, or directly looking at the stats and research papers. In this case, looking at the stats makes it blatantly obvious that your risk from the J&J vaccine is much, much lower than your risk from getting COVID, so if your choice is "J&J" or "no vaccine for another month or two", you should probably pick J&J.

[kordlessagain]

> I've already seen a bunch of anit-vaxers referring to this

It's not only a disservice, it's a biased way of thinking which only serves the one making the statement, given it allows them a way to alleviate their concerns about having received a level of uncertainty from their actions. I get them them because I also got that shot!