If you are visually impaired you may have to use a screen reader. If that screen reader cannot correctly 'say' the whitespace, it may be difficult to understand languages such as Python where indentation is significant.
How would a blind person code? They need a way to convert text on-screen to sound (or haptic feedback). Such a program can be easily used for C, because all the structure of C code is explicitly marked by its syntax - opening and closing braces, semicolons, macro beginnings and endings, etc. A C code reader can skip over any amount of whitespace, because none of it is semantic.
A Python screen reader would not have the same power. It would somehow have to communicate the significant whitespace to the user through sound. You cannot "remove the silence" when listening to a Python program, in the same way that you cannot strip out whitespace without changing the behaviour of the program.
In theory it should be possible to read out loud an "indent" and a "dedent" token whenever the indentation changes. That would be basically the same trick that Python's parser uses under the hood.
However, I don't know if there are any screen readers that have been taught to do that.
If you are visually impaired you may have to use a screen reader. If that screen reader cannot correctly 'say' the whitespace, it may be difficult to understand languages such as Python where indentation is significant.